... and nerve-related pain, with one-third still affected after 6 months. This challenges the view of WADII as purely muscle-related and highlights the need for nerve-focused assessments and treatments. whiplash associated disorders motor vehicle collision neuropathic pain nerve injury neuropathy ACCEPTED...

...*Martha Lopez Canul; Vivienne Nguyen; Antonio Inserra; Ella Nield; Hannah Billings; Gabriella Gobbi pain neuropathic pain psilocybin psychedelics © The Author(s) 2025. Published by Oxford University Press on behalf of CINP. 2025 This is an Open Access article distributed under the terms...

... Spinal cord injury (SCI) below-level neuropathic pain is a difficult condition to treat both pharmacologically and surgically. Successful treatment using surgically created lesions of the spinal cord dorsal root entry zone (DREZ), guided by intramedullary monitoring of neuronal electrical hyperactivity...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background The pathophysiology of pain in sickle cell disease (SCD) is complex and not fully understood. Neuropathic pain (NP) is an emerging theory of chronic pain in SCD. Nevertheless, assessment of NP is not a part of standard care...

... oxidative stress TRPA1 signalling neuropathic pain US National Institutes of Health 10.13039/100000002 NS136108 NS130138 Korea Health Technology R&D Project HI21C1062 National Research Foundation of Korea 10.13039/501100003725 NRF-2022M3E5E8081191 Parkinson’s disease...

... reserved. For permissions, please email: [email protected] 2024 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Neuropathic pain arises...

... of treatment effects. Personalized outcomes may be advantageous, particularly for clinical trials in populations with high inter-individual variability in pain qualities. chemotherapy-induced peripheral neuropathy personalized outcomes inter-individual variability neuropathic pain assay sensitivity...

..., Cambridge, UK). Corresponding author. Jungong Jin, Department of Neurosurgery, Xi 'an International Medical Center Hospital, No. 777, Xitai Road, Hightech Zone, Xi'an City, Shaanxi, China. Email: [email protected] 19 06 2024 28 07 2024 18 08 2024 Neuropathic pain is an unsolved clinical...

... carried out with Sigmaplot and Graphpad Prism. Additional details on all methods used can be found in the Supplementary material . Few studies have assessed the expression of LGI1 in regions of the nervous system outside of the brain. Given the link to neuropathic pain, we first wanted to analyse...

... for the Study of Pain and were approved by McGill University's downtown Animal Care Committee. All mice were 8 weeks of age when undergoing surgical procedures. Neuropathic pain was induced by performing spared nerve injury (SNI) ¹⁹ and chronic constriction injury (CCI) ²⁰ procedures...

... stimulation is also capable of reducing neural transmission in pathways made pathologically overactive by spinal cord injury. Debilitating spasms, spasticity and neuropathic pain are all common manifestations of hyperexcitable spinal responses to sensory feedback. Whereas spasms and spasticity can often...

... and prevented macrophage proinflammatory polarisation in VIPN mice. Conclusions Our results show that DMAC, acting through different mechanisms, effectively attenuates VIPN. chemotherapy neuropathic pain inflammation analgesia chalcone Coordenação de Aperfeiçoamento de Pessoal de Nível Superior...

... of neuropathic pain. This has spurred active exploration of treatment strategies leveraging nanomedicine for diseases, aiming for superior therapeutic outcomes. In this context, we have developed biodegradable nanoparticles made of polylactic-co-glycolic acid, loaded with triptolide (pCel), designed to alleviate...

...Elif Karabacak; Hazal Eken; Ilhem Dallali; Rana Arslan Correspondence: Adana City Training and Research Hospital Pharmacy, 4522 Street, No:1 Yuregır, Adana, Turkey. E-mail: [email protected] 29 11 2023 27 03 2024 Neuropathic pain is defined as pain resulting from lesions...

... patients aged 18 to 80 years with chronic upper extremity pain (CRPS and neuropathic pain such as peripheral neuropathy and post-laminectomy pain syndrome of the cervical spine) lasting for at least ≥3 months who received TSGB; 2) patients for whom temperature data for both hands were recorded before...

... volunteers were prospectively recruited for this study and served as a control group. Inclusion criteria for healthy controls were no neurological disease, absence of neuropathic pain or other sources of pain as well as absence of any contraindications for MRI. Fabry disease patients were recruited through...

... led to cessation of all related symptoms. The patient stopped taking aspirin, and has not needed to take any further medications for this condition. Erythromelalgia is a rare condition that is characterised by neuropathic pain and heat intolerance [ 1 , 2 , 4 ]. It commonly affects the upper...

... with chronic pain generally, a similar benefit might be expected in the management of chronic neuropathic pain (NeuP). However, to date, this has not been established, with existing systematic reviews on this topic being hampered by the scarcity of randomized controlled trials (RCTs). This review aimed...

... on satellite glial cell function has been performed with in vitro studies, but recent advances in calcium imaging and transgenic mouse models have enabled this first in vivo study of single-cell satellite glial cell function in mouse models of inflammation and neuropathic pain. We found...

... is also involved in the underlying mechanism of their insensitivity to neuropathic pain. 2-AG is synthesized from membrane phospholipids by sequential activation of phospholipase C (PLCβ1–4 and PLCγ1–2) and diacylglycerol lipase α/β (DGLα/β), whereas monoacylglycerol lipase (MGL) is critical...