... cited. Abstract Background This phase 2a study evaluated pharmacokinetics and safety of ceftazidime-avibactam (CAZ/AVI; combination dosed as fixed 4:1 ratio) in neonates and young infants with suspected/confirmed infections due to Gram-negative pathogens requiring intravenous antibiotics. Methods...

..., distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Ultraviolet (UV) light is dangerous to unpigmented organisms, inducing photodamage of cells and DNA. The transparent nematode Caenorhabditis elegans detects light and exhibits negative phototaxis...

..., further research is needed to establish standardized protocols for its long-term efficacy across diverse populations. The study highlights the need for more data on VSD in fracture management to validate its benefits. closure vacuum assisted negative-pressure wound therapy topical negative pressure...

... their integrity. Direct observation of EVs is critical, and negative staining with heavy metal salts is a standard technique in biological transmission electron microscopy for routine morphological analysis and experimental optimization. However, customizations are often required for specific objectives. Uranyl...

.../ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Negative pressure wound therapy has allowed for improved management of critical ill patients who requiring abdominal exploration by minimizing operation length...

..., challenges persist in machine learning (ML) models due to a scarcity of quality hard negative samples, shortcut learning, and limited generalizability to novel proteins. Results In this study, we introduce a novel approach for strategic sampling of protein-protein non-interactions (PPNIs) by leveraging...

.... Summary Background Data Results of randomized controlled trials (RCTs) may not be applicable to daily practice. Methods Outcomes of patients who had undergone curative surgery for node-negative NSCLC were retrospectively evaluated. They were either participants in an RCT (JCOG0707) or those excluded...

... tool of late-recurrence (beyond 5 years) in a series of hormone receptor-positive Human Epidermal Growth Factor Receptor 2 (HER2)-negative BC Spanish patients included in GEICAM studies. We included data from 4 randomized clinical trials in EBC patients and one BC registry. In the GEICAM/9805 (1999...

... with higher levels of stress exposure (β = -0.04) and negative appraisals (β = -0.07). Appraising stress as more upsetting had a detrimental influence on later-life disability for Black adults (occurring 11% earlier), but a protective effect for foreign-born Hispanic adults (occurring 20% later) compared...

... on the article page on our site—for further information please contact [email protected]. Abstract Background This real-world study describes the treatment landscape evolution after targeted therapy approval and associated survival outcomes for previously untreated metastatic triple-negative breast...

... of these individuals (highlighting a propensity to take up unskilled, low status job roles after leaving the child protection workforce); how they aligned notions of ‘stress’ and ‘burnout’ to their time in practice; and their assertion that the perceived negative depiction of the role informed their decision to leave...

... ). Eyestalk excision is considered the effective way to promote ovarian maturation, and CHH family are believed to regulate gonadal development ( Liu et al., 2020 ). CHH1, CHH2, and GIH2 negatively regulate ovarian development in Portunus trituberculatus (Miers, 1876) ( Xie et al...

... to decisions about investments in vaccination, yet they can be prone to inaccuracies. At the individual level, inaccuracies can be described in terms of the sensitivity and specificity of vaccination status. We estimated these quantities using a hierarchical Bayesian analysis of data from a test-negative study...

...) 83.13 <0.001 Note: DEBQ-RS, Dutch Eating Behavior Questionnaire at restraint subscale; NPSS-F, Negative Physical Self Scale at Fatness subscale; PAS, positive affective schedule; NAS, negative affective schedule; BMI, body mass index; NGlow, normal weight with low NPSS-F; NGhigh...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background A new definition for complicated coagulase-negative staphylococcal (CoNS) bacteremia was recently proposed. The aim of this study...

... is increasingly recognized: non-epidemic KS in men who have sex with men (MSM) who are HIV-negative. Our primary objective was to characterize non-epidemic KS to identify associated risk factors, presentation, treatment course, and prognosis of these patients. Patients and Methods This retrospective cohort...

.../standard_publication_model ) ABSTRACT SARS-CoV-2–infected individuals have reported a diverse collection of persistent and often debilitating symptoms commonly referred to as long COVID or post-acute sequelae of SARS-CoV-2 (PASC). Identifying PASC and its subphenotypes is challenging because available data are “negative...

... to develop complications. The prevalence of monomicrobial and polymicrobial BSI remained stable during hospitalization, with gram-positive pathogens such as Staphylococcus aureus most common during the first week but with gram-negative pathogens, particularly MDR Pseudomonas aeruginosa...

... recurrence 33 3.1 Abbreviation: TNBC, triple-negative breast cancer. Breast cancer is the most common cancer worldwide. ¹ It is a heterogeneous disease comprising different subtypes, ² each with distinct clinical outcomes and therapeutic responses. ³ Triple...

... method based on schizotypy has proven to be a highly cost-effective strategy for unraveling etiological factors for schizophrenia-spectrum disorders, there is a paucity of longitudinal studies with nonclinical populations. This study analyzed the predictive validity of positive and negative schizotypy...