... with previous studies, IFNG-stimulated murine bone marrow derived macrophages effectively restricted Mtb replication. These data suggest that Mtb resists IFNG-stimulated immunity within human macrophages with implications for distinct host species immune responses. In contrast to murine macrophages, we...

... >12 weeks post-acute SARS-CoV-2 infection, and compared them to 25 convalescent controls without symptoms. We performed immune phenotyping of T and B cell subsets, assessed SARS-CoV-2-specific responses using activation-induced marker (AIM) flow cytometry for T cells, and tetramer staining of spike...

... in the innate immune response. Currently, a wide range of research has indicated the crucial importance of NLRP3 in various inflammatory conditions. Similarly, the NLRP3 inflammasome plays a significant role in preserving intestinal balance and impacting the advancement of diseases. In addition, several...

... death, as well as lytic forms of cell death. Recently, caspase-8 has been identified as an integral component of PANoptosomes, multi-protein complexes formed in response to innate immune sensor activation. Several innate immune sensors can nucleate this caspase-8–containing PANoptosome complex to drive...

...-directed therapy against M. abscessus infection, especially in people with CF who cannot access ETI treatment. Mycobacterium abscessus cystic fibrosis liposomes ETI host-directed therapy pathogen-directed therapy innate immunity phosphatidylinositol 5-phosphate Italian Cystic...

... reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract A gut–brain axis influenced by host innate immunity and resident microbiota has been implicated in neurological conditions including Alzheimer’s disease. However, the precise connection of innate...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Recent studies have challenged the traditional view of innate immunity as non-specific and transient by demonstrating that innate immune cells can develop immune memory in response to various activating factors, a phenomenon known as trained...

... to foreign antigens, plays a crucial role in cancer immunity. However, its role in MSS/pMMR colorectal cancer (CRC) remains unclear. In this study, we demonstrated that ICOS expression decreases as the tumor stages advance and that high ICOS expression is associated with a favorable prognosis in MSS/pMMR CRC...

... in any medium, provided the original work is properly cited. Abstract Proteases are essential enzymes in plants that play multiple roles in immunity, including molecular recognition, programmed cell death, and the degradation of pathogen proteins. During plant-pathogen interactions, both organisms have...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Lung-resident conventional dendritic cells (cDCs) coordinate immune responses to respiratory viruses in the respiratory tract or after migration to mediastinal lymph nodes (mLN). Migratory DCs include cDC1s (CD103⁺XCR1...

... type N polypeptide 2 (Ptprn2) and meiosis 1 associated protein (M1ap)). These DEGs are highly involved in angiogenesis, the immune system, and inflammatory signaling pathways, underscoring the multifaceted nature of FGR pathology. This study contributes to the understanding of FGR...

... and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract The potato immune receptor Gpa2 confers host-specific resistance...

...Chelsea S Lutz; Huong Q Nguyen; David L McClure; Nina B Masters; Min-hsin Chen; Heather Colley; Sun B Sowers; Stephen N Crooke; Mona Marin Correspondence: Chelsea S. Lutz, PhD, MPH, Epidemic Intelligence Service, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases...

... to better delineate effects downstream of NKG2D signaling in human, rather than mouse, NK cells. Graphical Abstract Graphical Abstract Source: Created in BioRender. Bedrosian, Z. (2025). https://BioRender.com/q6cm34h . cross-tolerization NK cells NKG2D cytokines tumor immunity V Foundation...

... body is constantly exposed to pathogens and equipped with a highly elaborate immune system to fight against invading pathogens. The first line of defence is the innate immune system. It has evolved to detect conserved microbial molecular patterns, dubbed pathogen-associated molecular patterns (PAMPs...

... This review provides a broad overview of lessons learned in the five years since COVID-19 was identified. It is a bimodal disease, starting with an initially virus-driven phase, followed by resolution or ensuing inappropriate immune activation causing severe inflammation that is no longer strictly virus...

... IgG antibody humoral immunity households ACCEPTED MANUSCRIPT The Journal of Infectious Diseases MAJOR ARTICLE Strength and durability of RSV pre-fusion F IgG following infection and exposure in a household cohort, 2014-2022 Kalee E. Rumfelt, MPH1, Casey Juntila, MS1, Matthew Smith, MPH1, Amy...

... defect during virus exposure compared to NK cells deficient in a single factor. Thus, our study reveals a cooperative interplay between IRF4- and IRF8-dependent transcriptional networks in regulating NK-cell antiviral responses. Innate immunity interferon regulatory factor natural killer cells...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Although immune responses to bacillus Calmette-Guerin (BCG)-vaccination and susceptibility to pediatric tuberculosis (TB) vary across individuals, the underlying cellular mechanism regulating this heterogeneity is poorly understood. We used...

... for pulmonary cNK cells in preventing viral dissemination from infected lungs. MCMV lung NK cells innate immunity mouse Brown Respiratory Research Training Program National Heart, Lung, and Blood Institute 10.13039/100000050 T32 HL134625 F31 HL172690 Human cytomegalovirus (HCMV) is a β...