... Y degeneration leads to the formation of sRNAs that can interact with both X and Y genes in males due to X-Y sequence homology. Our work calls for future investigation of the impact of these sRNAs generated from the Y chromosome on X gene expression in males. Graphical abstract Graphical Abstract...

... and measured body weight, histological changes, active and sleep behavior, and hypothalamic gene expressions. Body fattening, gonadal recrudescence, and organ-specific lipid accumulation were observed during the breeding phase. Increased allopreening behavior coupled with reduced sleep suggested increased...

... Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Extensive studies have demonstrated significant gray matter atrophy in patients with Parkinson’s disease (PD); however, the underlying gene expression mechanisms remain largely unknown...

... includes hundreds of type-2 vomeronasal receptors and olfactory receptors, representing the two largest gene families found in the genome. To investigate the biological importance of this chemoreceptor diversity, we assessed gene expression in the eastern diamondback rattlesnake (Crotalus...

... ovulation, and provides a unique opportunity to interrogate gene regulatory mechanisms by C/EBPα/β during different preovulatory time windows and the impact of dysregulating C/EBPα/β on ovulation-associated biological processes. Our study revealed that C/EBPα/β regulate gene expression and distinct...

... matrix and smooth muscle genes to induce a myofibroblast phenotype, thereby possibly contributing to leiomyoma pathogenesis. FKBP51 HSD11β1 Leiomyoma Glucocorticoid Signaling Gene Expression 1 Increased HSD11 1 Expression in Human Leiomyomatous Uteri: Implication for 2 Enhanced Glucocorticoid...

... in their genome, ⁸ with a significant portion located in non-coding regions, impacting gene expression and splicing patterns. ⁹ RNA-sequencing (RNA-seq) enables the quantification of gene expression levels, identification of novel transcripts, alternative splicing and gene fusion events...

... microbial imbalances as potential biomarkers for early CRC detection and underscore the therapeutic promise of probiotic-derived CFSs, presenting innovative, non-invasive strategies for managing CRC-associated inflammation. Cell-free supernatants Colorectal cancer Gene expression IL-6 Microbiota...

... reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Given the imminent threat of global warming and rising water temperatures in Austria, this study investigated the effects of elevated temperature on gene expression, energy reserves, and cellular...

... two-sample MR, colocalization, and SMR/HEIDI analyses. These included one CpG site in CRBLM, 286 in DLPFC, one in FCTX, two in PONS, and two in TCTX ( Supplementary Table 6 ). To investigate whether DNA methylation of these CpGs in DLPFC influences ad risk through regulating gene expression...

... biosensor cell-free gene expression enzyme engineering Echo 525 liquid handler biofoundry Research Initiative Program KGM1302511 Ministry of Science and ICT, South Korea 10.13039/501100014188 Basic Science Research Program / RS-2024-00336627 Bio & Medical Technology Development Program...

..., EEF1DP7 and VIL1 are also associated with hypertension in transcriptome-wide association studies. Our results suggest that living in poverty influences inflammation and the risk for cardiovascular disease through gene expression changes in immune cells. Poverty Gene Expression RNA-seq Health...

... in the regulation of gene expression in eukaryotes. It is involved in important physiological processes such as development, immune response and metabolic regulation. During gene expression regulation, chromatin remodelers slide nucleosomes along genomic DNA and play a major role in chromatin organization. Chd1...

...-supplemented diet (C28+HS). Growth sampling was performed every 30 d, and the final growth metrics, survival, immune responses, and gene expression were evaluated poststudy. Results Monthly sampling showed that growth performance in all groups declined with temperature reduction and was lowest during...

... that of untreated tissue. This study investigated how intramuscular lidocaine injection influenced skeletal muscle gene expression in sheep, aiming to understand how transcriptomic changes could affect data interpretation. Approximately 10 min before euthanasia, the left biceps brachii muscle from each...

... cited. Abstract Motivation The sophisticated lfcShrink() function implemented in the DESeq2 package for differential gene expression analysis aims to reduce noise from low read count and/or highly variable genes in bulk RNA-sequencing data, thus circumventing the need for arbitrary filtering...

... sequence. Importantly, expression profiling using a Zcf11 knock-down strain revealed that this factor is a negative regulator of meiotic genes expression as well as some genes involved in mating. Thus, regulation of the expression of meiotic genes is functional in this organism reinforcing the view...

... of X upregulation at the transcript level in eutherian mammals, Ohno's hypothesis is strongly supported in both nematode lineages investigated. Caenorhabditis elegans Brugia malayi sex chromosome Ohno's hypothesis gene expression Significance Ohno proposed that, in the origin...

... of ACE to a microRNA dataset, a neuroblastoma gene expression dataset, and a Huntington’s disease dataset resulted in some novel findings that were missed by existing methods. dependence factor model false discovery rate gene expression high throughput experiment multiple testing National Natural...

... in gestation to determine effects on piglet tissue mineral concentrations and gene expression. Ten sSows per treatment were assigned to dietary treatments: 1) Control – sows fed a corn-soybean meal-based diet containing 206 ppm total supplemental zinc supplied by zinc hydroxychloride from mating to farrowing...