... into action potentials is the rate-limiting step of communication in neural networks. The efficiency of this intracellular information transfer also powerfully shapes stimulus representations in sensory cortices. Using whole-cell recordings and information-theoretic measures, we show herein that somatic...

... pyramidal cells under normal conditions revealed that BLA- or PAG-projecting pyramidal cells fired action potentials more frequently than did non-projecting pyramidal cells. These results suggest that BLA- or PAG-projected dmPFC pyramidal cells express empathy by suppressing their excitability...

...Frederic Franceschi; Linda Koutbi; Baptiste Maille Secondly, no compound motor action potential (CMAP) values were reported in the study. The authors defined PN stunning as a drop in CMAP amplitude > 30% after application of PFA. This threshold is arbitrary. Incomplete CMAP recovery is probably...

...Hae Jin Kim; Charles E Norton; Scott D Zawieja; Jorge A Castorena-Gonzalez; Michael J Davis contractile dysfunction lymph pump metabolic syndrome reactive oxygen species action potential mitochondrial electron transport chain Spontaneous contractions were recorded with equal input and output...

... are predominantly expressed in the excitatory neurons of the CNS, where they contribute to the generation and propagation of action potentials. De novo missense mutations in SCN2A can lead to neurodevelopmental disorders of various severity, including early-infantile developmental and epileptic...

... patients with sinus rhythm (SR) or atrial fibrillation (AF). Currents were measured in human atrial cardiomyocytes (aCM) and compared with hiPSC-aCM and used to model I_Ks contribution to action potential (AP) shape. Action potential was recorded by sharp microelectrodes. HMR-1556 (1 µM...

.../ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Graphical Abstract Graphical Abstract Electrocardiogram Action potential duration Excitability Kir2.1-Nav1.5 channelosome Atrial and ventricular arrhythmias Detailed...

... to Einthoven’s refinement of the electrocardiogram (ECG). ³ Microelectrode recordings from Purkinje fibres generated the first recorded cardiac action potentials. ⁴ Subsequent single-cell techniques, such as voltage and patch-clamping, informed our understanding of distinct action...

... Bruegmann; Ingo Kutschka; Katrin Streckfuss-Bömeke; George Kensah; Lukas Cyganek; Wolfram H Zimmermann; Niels Voigt Graphical Abstract Graphical Abstract Stem cells Ion channel Action potential Atrial fibrillation Optogenetics Corresponding author. Tel: +00495513965174; fax: +00495513965169, E-mail...

... methodology, we studied the effects of tramadol, fentanyl, and codeine on currents of human Na_v1.5 channels stably expressed in HEK293 cells and on action potential (AP) properties of freshly isolated rabbit ventricular cardiomyocytes. In fully available Na_v1.5 channels (holding...

... differences in signaling dynamics within cortical circuitry. This approach offers a unique opportunity to investigate conduction in populations of axons based on their targeting specificity. axonal conduction action potential propagation velocity inhibitory interneurons parvalbumin somatosensory cortex...

... therapies hinges on the assumption that myocytes from the same region of a single heart have similar, if not identical, action potential waveforms and drug responses. On the contrary, recent experiments reveal significant heterogeneity in uncoupled healthy myocytes both from different hearts as well as from...

... of action potentials (APs) in internodal cells of Nitellopsis obtusa and thallus of Marchantia polymorpha recorded by intracellular microelectrodes. Upper panel: original traces of APs evoked by electrical stimulation. Lower panel: proposed sequences of ion fluxes in different phases...

... Corresponding author. Email: raffaele.coppini@unifi.it . 16 11 2021 14 04 2022 01 06 2022 Graphical Abstract Graphical Abstract Action potentials, QT/ED intervals, and relaxation...

.../chorus/standard_publication_model ) Docosahexaenoic acid Repolarization Action potential duration Long QT syndrome QT normalization Ion currents Rabbit models Genotype-specific therapy German Heart Foundation 10.13039/501100005971 F/02/14 National Heart Lung and Blood Institute NHLBI...

..., assessing integration in terms of total dendritic length and action potential rise speed. As could be hypothesized, greater network centrality related to better memory performance. Moreover, greater network centrality correlated with more integrative properties at the cellular level across patients. We...

... thickness was measured in 91 slices from 36 of these subjects. From 25 subjects, full morphological reconstructions of 71 neurons were obtained. Action potentials were recorded in 149 neurons from 35 subjects. Although the MTG by itself is not essential for speech (is not part of classical Broca...

... method to investigate the effects of Cd²⁺ on ventricular action potentials (APs) and major ion currents in rainbow trout (Oncorhynchus mykiss) ventricular myocytes. Trout were acclimated to +4 °C, and APs were measured at the acclimated temperature and elevated temperature (+18 °C...

... of the timing of two currents thought to play a key role in generation oscillations of the ventricular action potential in humans. The inward L-type calcium current (I_CaL) occurs early during phases 0, 1, and 2 and the outward potassium current (I_Ks) occurs later during phases 2 and 3...

... it requires the presence of additional pathological factors. Methods and results Action potentials (APs) and arrhythmogenic spontaneous diastolic activities were measured in isolated murine ventricular, rabbit atrial, and ventricular myocytes acutely exposed to high glucose. Acute hyperglycaemia increased...