...Farhana Yasmin; Katie F M Marwick; Daniel W Hunter; Sarfaraz Nawaz; Grant F Marshall; Sam A Booker; Giles E Hardingham; Peter C Kind; David J A Wyllie Over the last decade, genetic studies have reported a range of ultra-rare variants in GluN NMDA receptor subunits ^{4 , 5}...

... protein kinase (AMPK) and functions as a partial agonist of the NMDA receptor glycine binding site, both of which have been associated with reducing cue-induced reinstatement4.5.6. Aims & Objectives The study aimed to both identify the brain regions associated with betaine's reduction effect...

... RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background NMDA receptor (NMDAR) is an essential glutamate receptor and as a contributor to neurodegenerative disorder1,2. Until now, NMDAR (especially...

... RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is a condition that was only identified relatively recently. It often presents...

..., Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine. Biol Psychiatry Jul 15 2023;94(2):164- 173. 3. Govani V, Shastry AM, Iosifescu DV, et al. Augmentation of learning in schizophrenia by d-serine and auditory remediation is related to auditory...

... RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background NMDA receptor antagonists play a vital role in new fear memory learning and extinction. Crucial to post-retrieval extinction processes...

... Projections to the Basolateral Amygdala. Neuroscience, 388, 274-283. social dominance anxiety stress susceptibility medial preoptic area NMDA receptor Abstracts CINP2024 testing. Neither 5-HTP (500 mg/kg) nor fenfluramine (5 mg/ kg) administered immediately after fear conditioning impaired freezing...

... is properly cited. Abstract NMDA receptors (NMDARs) play essential roles in neuronal development, survival, and synaptic plasticity, to name a few. However, dysregulation in receptors' activity can lead to neuronal and synaptic damage, contributing to the development of various brain pathologies. Current...

... cervical lymph nodes, might contribute to fine-tune the polyclonal immune response. Maudes et al. have developed a mouse model of anti-NMDAR encephalitis, an autoimmune disease mediated by autoantibodies against the GluN1 subunit of the NMDA receptor. The model provides a platform for studying...

... administration of haloperidol with UNC9994 at low doses represents a promising approach to ameliorate symptoms of schizophrenia. The combined drug regimen elicits synergistic effects specifically on pAkt-S473, suggesting it as a potential biomarker for antipsychotic actions. NMDA Grin1 MK-801 UNC9994...

... proximity to ligands bound to the agonist and antagonist binding sites being a key predictive feature for both variant pathogenicity and molecular functional consequences. Leveraging distances from ligands, we developed two machine-learning based predictors for NMDA variants: a pathogenicity predictor which...

... pleocytosis (white blood cell count of more than five cells per mm³)   • MRI features suggestive of encephalitis  3. Reasonable exclusion of alternative causes Graus criteria for probable NMDA receptor encephalitis ⁴⁴ Diagnosis can be made when all three...

... permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background and Hypothesis N-Methyl-d-aspartate receptor (NMDA-R) hypofunctioning has been hypothesized to be involved in circuit dysfunctions...

... on the mode of action of NMDAR-Ab and, probably, our understanding of (extra)synaptopathies. Jamet et al. explore the effects of autoantibodies against the NMDA receptor on rodent hippocampal neurons. They describe the molecular cascade triggered by the autoantibodies in the first minutes to hours...

...Sisi Shen; Ran Wei; Yu Gao; Xinyuan Yang; Guoning Zhang; Bo Yan; Zhuoling Xiao; Jinmei Li Science and Technology Department of Sichuan Province 10.13039/501100004829 2019YFH0145 National Natural Science Foundation of China 10.13039/501100001809 81571272 Anti-NMDA receptor (N-methyl-D...

..., or loss of consciousness, resulting from abnormal electrical brain activity. It can have both genetic and acquired causes, with interaction of these factors in many cases. Auto-antibodies against synaptic receptors have been detected in a number of neurological conditions such as anti-NMDA receptor...

... et al. 2022 ; Friston 2022 ). Various studies using computational modeling ( Rolls et al. 2008 ; Qian et al. 2020 ), molecular investigations (NMDA, GABA) in animal models ( Kehrer et al. 2008 ; Davenport et al. 2019 ), and human PET ( Narendran et al. 2020 ) studies suggest an atypical EIB...

...Tsung-Yu Pan; Yi-Ju Pan; Shih-Jen Tsai; Che-Wen Tsai; Feng-Yi Yang Abstract Background and Hypothesis Treatment of schizophrenia remains a major challenge. Recent studies have focused on glutamatergic signaling hypoactivity through N-methyl-D-aspartate (NMDA) receptors. Low-intensity pulsed...

... model. This approach could represent a promising strategy for fast and specific treatment of NMDAR encephalitis. autoimmune encephalitis antibodies bodies NMDA receptor synapses memory German Research Foundation 10.13039/501100001659 HA6386/9-1 HA6386/10-1 GE2519/8-1 GE2519/9-1 PR1274/4-1...

... or accompany those rewards, is an essential adaptive function for survival. Methods In this study, we investigated the mechanisms underlying the acquisition and performance of conditioned approach learning with a focus on the role of muscarinic acetylcholine (mACh) and NMDA glutamate receptors...