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Keywords: Scalability
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Journal Article
FEATURED
Principles and implementation strategies for equitable and representative academic partnerships in global health informatics research
Elizabeth Campbell and others
Journal of the American Medical Informatics Association, Volume 32, Issue 5, May 2025, Pages 958–963, https://doi.org/10.1093/jamia/ocaf015
Published: 13 February 2025
... is key to scalability and long-term success for projects in the global health informatics (GHI) domain. This paper presents key strategies for incorporating principles of health equity in the GHI project lifecycle. Materials and Methods The American Medical Informatics Association (AMIA) GHI Working...
Journal Article
Fibrillar adhesives with unprecedented adhesion strength, switchability and scalability
Changhong Linghu and others
National Science Review, Volume 11, Issue 10, October 2024, nwae106, https://doi.org/10.1093/nsr/nwae106
Published: 20 March 2024
... fibrils on the adherend when Dahlquist criterion (i.e. E <1 MPa) is satisfied. (ii) Strong and scalable adhesion in the DMT-like regime. After attachment, the adhesive fibrils become stiff when transitioning into the glass-phase upon reverse stimulation. When loaded in the stiff-state...
Journal Article
Balanced Off-Chain Payment Channel Network Routing Strategy Based On Weight Calculation
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Ya Liu and others
The Computer Journal, Volume 67, Issue 3, March 2024, Pages 907–922, https://doi.org/10.1093/comjnl/bxad029
Published: 05 April 2023
... waiting queue to avoid the failure of transaction caused by channel congestion, improving transaction throughput. However, nodes in Spider need to maintain the global network state, and the scalability could be better. However, Hide&Seek [ 15 ] is the latest rebalancing mechanism, which maximizes...
Journal Article
A generic parallel framework for inferring large-scale gene regulatory networks from expression profiles: application to Alzheimer’s disease network
Softya Sebastian and others
Briefings in Bioinformatics, Volume 24, Issue 1, January 2023, bbac482, https://doi.org/10.1093/bib/bbac482
Published: 03 December 2022
...) to infer large networks in parallel without compromising original quality. We implement the proposed generic parallel framework and seamlessly integrate 15 publicly available inference methods. We assess the scalability of 15 state-of-the-art inference methods together with their performance using...
Journal Article
EDITOR'S CHOICE
Advancing disease genomics beyond COVID-19 and reducing health disparities: what does the future hold for Africa?
Chibuike Ibe and others
Briefings in Functional Genomics, Volume 22, Issue 3, May 2023, Pages 241–249, https://doi.org/10.1093/bfgp/elac040
Published: 24 November 2022
..., we highlighted key initiatives in genomics research and efforts to address health challenges facing the diverse and fast-growing populations on the continent. We explore the scalability of genomic tools and techniques to tackle a broader range of infectious diseases in Africa, a continent...
Journal Article
EDITOR'S CHOICE
Intensification of Implementation Strategies: Developing a Model of Foundational and Enhanced Implementation Approaches to Support National Adoption and Scale-up
Jaime M Hughes and others
The Gerontologist, Volume 63, Issue 3, April 2023, Pages 604–613, https://doi.org/10.1093/geront/gnac130
Published: 27 August 2022
... is conducive to evaluating feasibility and scalability of implementation strategies on a national level. In previous work evaluating implementation of three EBPs for older Veterans (hospital-based walking, caregiver skills training, group physical therapy), we found facilities varied in their need...
Journal Article
Scalable batch-correction approach for integrating large-scale single-cell transcriptomes
Xilin Shen and others
Briefings in Bioinformatics, Volume 23, Issue 5, September 2022, bbac327, https://doi.org/10.1093/bib/bbac327
Published: 10 August 2022
.../standard_publication_model ) Abstract Integration of accumulative large-scale single-cell transcriptomes requires scalable batch-correction approaches. Here we propose Fugue, a simple and efficient batch-correction method that is scalable for integrating super large-scale single-cell transcriptomes from diverse sources...
Journal Article
Scalability and robustness of spectral embedding: landmark diffusion is all you need
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Chao Shen and Hau-Tieng Wu
Information and Inference: A Journal of the IMA, Volume 11, Issue 4, December 2022, Pages 1527–1595, https://doi.org/10.1093/imaiai/iaac013
Published: 02 August 2022
... it scalable to handle ’big data’. On the other hand, the robustness property is less explored and there exists only limited theoretical results. Motivated by the need of handling such data, recently we proposed a novel spectral embedding algorithm, which we coined Robust and Scalable Embedding...
Journal Article
Spacemake: processing and analysis of large-scale spatial transcriptomics data
Tamas Ryszard Sztanka-Toth and others
in
GigaScience
GigaScience, Volume 11, 2022, giac064, https://doi.org/10.1093/gigascience/giac064
Published: 19 July 2022
... across inputs from different technologies. Findings Here, we present spacemake, a modular, robust, and scalable spatial transcriptomics pipeline built in Snakemake and Python. Spacemake is designed to handle all major spatial transcriptomics data sets and can be readily configured for other...
Journal Article
How to solve big problems: bespoke versus platform strategies
Atif Ansar and Bent Flyvbjerg
Oxford Review of Economic Policy, Volume 38, Issue 2, Summer 2022, Pages 338–368, https://doi.org/10.1093/oxrep/grac009
Published: 18 May 2022
... and schedule, and scalability outcomes of their respective space missions. Our reference class dataset consists of 203 space missions spanning 1963–2021, of which 181 missions belong to NASA and 22 belong to SpaceX. We find that SpaceX’s platform strategy was 10X cheaper and 2X faster than NASA’s bespoke...
Journal Article
Fast Increased Fidelity Samplers for Approximate Bayesian Gaussian Process Regression
Kelly R. Moran and Matthew W. Wheeler
Journal of the Royal Statistical Society Series B: Statistical Methodology, Volume 84, Issue 4, September 2022, Pages 1198–1228, https://doi.org/10.1111/rssb.12494
Published: 19 April 2022
... log n ) , which allows for scalability to previously unimplementable data sizes. The NNGP is a well-defined spatial process, with sparse precision matrices available in closed form enabling the aforementioned computation gains. However, this sparsity guarantees the approximating covariance...
Journal Article
Decentralized Data Flows for the Functional Scalability of Service-Oriented IoT Systems
Damian Arellanes and others
The Computer Journal, Volume 66, Issue 6, June 2023, Pages 1477–1506, https://doi.org/10.1093/comjnl/bxac023
Published: 25 March 2022
... the separation of control and data for realizing decentralized data flows between atomic services, in order to efficiently support environments that generate huge volumes of data continuously. Furthermore, existing approaches only consider vertical and horizontal scalability. It is important to mention...
Journal Article
Massive data clustering by multi-scale psychological observations
Shusen Yang and others
National Science Review, Volume 9, Issue 2, February 2022, nwab183, https://doi.org/10.1093/nsr/nwab183
Published: 08 October 2021
... results; (ii) high scalability—the algorithm should easily scale to massive datasets; (iii) universality—the algorithm should be effective for various tasks without any prior assumption; and (iv) user friendliness—the algorithm should be very easy to use in practice. National Key Research and Development...
Journal Article
BIGwas: Single-command quality control and association testing for multi-cohort and biobank-scale GWAS/PheWAS data
Jan Christian Kässens and others
in
GigaScience
GigaScience, Volume 10, Issue 6, June 2021, giab047, https://doi.org/10.1093/gigascience/giab047
Published: 29 June 2021
... a considerable computational challenge and are carried out by large scientific groups under great expenditure of time and personnel. Automating these processes requires highly efficient and scalable methods and software, but so far there is no workflow solution to easily process 1 million GWAS samples...
Journal Article
Design of a New Distributed NoSQL Database with Distributed Hash Tables
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Agustín San Román Guzmán and others
Logic Journal of the IGPL, Volume 30, Issue 4, August 2022, Pages 566–577, https://doi.org/10.1093/jigpal/jzab003
Published: 17 March 2021
... for almost any application. However, with the growth of the Internet in recent decades, both in the number of users and in the amount of information, those centralized models began to suffer availability and scalability issues. To address those issues, the use of decentralized architectures and alternative...
Journal Article
On the Behaviour of p-Adic Scaled Space Filling Curve Indices for High-Dimensional Data
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Patrick Erik Bradley and Markus Wilhelm Jahn
The Computer Journal, Volume 65, Issue 2, February 2022, Pages 310–330, https://doi.org/10.1093/comjnl/bxaa036
Published: 13 July 2020
...Patrick Erik Bradley; Markus Wilhelm Jahn Corresponding author: [email protected] This article has a similar aim as [ 15 ] in that the scalability of the Hilbert curve should be exploited to produce a scalable index whose local precision adapts to the local density of the point cloud...
Journal Article
The democratization of bioinformatics: A software engineering perspective
Brendan Lawlor and Roy D Sleator
in
GigaScience
GigaScience, Volume 9, Issue 6, June 2020, giaa063, https://doi.org/10.1093/gigascience/giaa063
Published: 20 June 2020
... to bioinformaticians. In the same way that cloud computing has democratized access to distributed systems engineering for generalist software engineers, access to scalable and reproducible bioinformatic engineering can be democratized for generalist bioinformaticians and biologists. We present solutions, based on our...
Journal Article
Virtual Block Group: A Scalable Blockchain Model with Partial Node Storage and Distributed Hash Table
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Bin Yu and others
The Computer Journal, Volume 63, Issue 10, October 2020, Pages 1524–1536, https://doi.org/10.1093/comjnl/bxaa046
Published: 08 May 2020
... at addressing the node storage scalability problem. Adopting the VBG model, each node only needs to store part of block data and saves the VBG storage index to distributed hash table by taking block data as a resource, thus improving the query efficiency of block data. With the incentive mechanism of block data...
Journal Article
Bayesian sparse multiple regression for simultaneous rank reduction and variable selection
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Antik Chakraborty and others
in
Biometrika
Biometrika, Volume 107, Issue 1, March 2020, Pages 205–221, https://doi.org/10.1093/biomet/asz056
Published: 23 November 2019
... Scalability Shrinkage Variable selection Suppose, for each observational unit , we have a multivariate response on variables of interest, along with information on possible predictors , a subset of which are assumed to be important in predicting the responses. Let denote...
Journal Article
Towards scaling elementary flux mode computation
Ehsan Ullah and others
Briefings in Bioinformatics, Volume 21, Issue 6, November 2020, Pages 1875–1885, https://doi.org/10.1093/bib/bbz094
Published: 20 November 2019
..., three conditions must be met to label as an ‘elementary flux mode’ or ‘elementary pathway’: The biggest challenge in EFM analysis is its scalability to allow for the analysis of genome-scale models. From a computational complexity perspective, the lack of scaling is understandable. A problem...
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