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Ruihan Li, Yuqi Tang, Wenjun Huang, Rong Li, Jiaqi Liu, The Roles of Apolipoprotein A1-Binding Protein in Metabolic Diseases, Nutrition Reviews, 2025;, nuaf021, https://doi.org/10.1093/nutrit/nuaf021
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Abstract
Metabolic disorders, including atherosclerosis, diabetes, and metabolic dysfunction–associated steatotic liver disease, are closely related to increased cardiovascular risks, significantly harming human life and health. Apolipoprotein A1-binding protein (AIBP), a multifunctional protein, plays crucial role in cholesterol metabolism. AIBP exerts an important action in managing metabolic diseases by interacting with apolipoprotein A-I and ATP-binding cassette transporter A1 activities to regulate high-density lipoprotein)–mediated cholesterol transport and to maintain lipid homeostasis. In addition, AIBP suppresses inflammatory stress and abnormal angiogenesis, and acts as an NAD(P)HX epimerase to optimize energy metabolism. In this review, the multiple roles of AIBP in clinical metabolic diseases are summarized, and AIBP is proposed to be a potential therapeutic target against metabolic diseases.
- angiogenesis
- apolipoproteins
- atherosclerosis
- hypertension
- heart disease risk factors
- diabetes mellitus, type 2
- cholesterol
- homeostasis
- high density lipoproteins
- energy metabolism
- membrane transport proteins
- metabolic diseases
- social role
- apolipoprotein a-i
- lipids
- stress
- cholesterol transport
- cholesterol metabolism
- metabolic dysfunction-associated steatotic liver disease