...) are transcription factors acutely induced by the luteinizing hormone surge and crucial for ovulation and granulosa cell luteinization. However, biological processes and their regulatory mechanisms downstream of C/EBPα/β in the preovulatory ovary are not completely understood. To address this knowledge gap, we...

... remain unclear. By integrating proteomic, transcriptomic and metabolomic data from peach fruit following UV-B irradiation, we discovered that the detached fruit responds to UV-B by suppressing the biosynthesis of the flavor-related monoterpene linalool. We identified PpMADS2, a transcription factor...

... of cells that can differentiate into osteoclasts have enhanced inflammatory gene expression at least partly due to changes in their chromatin. Overall, this data suggests that environmental signals at different skeletal sites may regulate the expression of genes. inflammation transcription osteoclasts...

... in videos should be easier to understand. Strengths and Limitations This study is the first scientific analysis of YouTube video transcripts on PE using AI, focusing specifically on English content, which limits its applicability to non-English speakers and other platforms. Exclusions of silent...

... Transcription Brain Damage O RIGIN A L U N EDITED M AN U SCRIPT Beyond the ends: Potential implications of Telomeric Repeat-Containing RNA (TERRA) for CNS Diseases Hadjer Namous1, Raghu Vemuganti1,2 1Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, 53792, USA and 2William S...

..., accelerates testing, and facilitates reliable large-scale screening. These findings highlight its potential to overcome current HTS limitations, advancing enzyme screening and accelerating the Design-Build-Test-Learn cycle for sustainable biomanufacturing. Graphical Abstract transcription factor-based...

... families. The variant creates a MEF2-binding site and presence of the variant allele or MEF2 co-expression enhanced transcriptional activity. dCas9-activator/repressor assays showed that KCNB1 was the only gene consistently regulated by the locus and 4C experiments in AC16 cells and human muscle...

... reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract R-loops (RNA/DNA hybrids) are caused by defects in RNA transcription or processing, and their level heavily correlates with genome instability and human disease. Most current yeast methods for R...

...Kazutaka Futagami; Masayuki Tsuzuki; Mika Yoshida; Yuichiro Watanabe liverwort Marchantia polymorpha gemma gemma cup notch microRNA RKD transcription factor R2R3MYB transcription factor Accepted Manuscript MpmiR319 promotes gemma/gemma cup formation in the liverwort Marchantia...

...Jesica Raineri; Enrique Montero Bulacio; Mabel Campi; Margarita Portapila; María Elena Otegui; Raquel Lía Chan Accepted Manuscript The sunflower transcription factor HaHB11 increases soybean grain number and heat tolerance across multi-season field trials Raineri, Jesicaa; Montero Bulacio, Enriqueb...

..., and transcriptional dysregulation are two hallmarks of tumors. However, the precise influence of lactate on epigenetic modifications at a genome-wide level and its impact on gene transcription in tumor cells remain unclear. We conducted an analysis of genome-wide histone H3 lysine 18 lactylation (H3K18la...

... at genes still transcriptionally misregulated in h2a.z + HsH2A.Z.1 plants. Of the overexpressed genes in h2a.z plants not complemented by HsH2A.Z.1, GO analysis identified an enrichment for secondary metabolism pathway genes, while GO analysis of underexpressed genes did...

... Graphical Abstract Figure. In a human fungal pathogen, the putative transcription factor Zcf11 has no known function. Here, it is shown that Zcf11 is a negative regulator of genes involved in meiosis. 28 11 2024 22 03 2025 01 04 2025 22 04 2025 © The Author(s...

... binding transcription activator (CsCAMTA) protein was functionally characterized based on yeast one-hybrid screening assay and previous transcriptomics. CsCAMTA is mainly localized in the nucleus and binds to the G-box (CACGTC) cis-element in the CsFEX1 promoter as a transcription...

... derivative chiral transcription helical nanofibers Japan Society for the Promotion of Science 10.13039/501100001691 KAKENHI 10.13039/501100001691 19K22116 21K14504 24K17592 The synthetic organic chemistry of chiral molecules is a critical research area due to its essential role in developing...

...Neelima Thottappillil; Zhao Li; Xin Xing; Shreya Arondekar; Manyu Zhu; Masnsen Cherief; Qizhi Qin; Myles Zhou; Mary Archer; Kristen Broderick; Bruno Pèault; Min Lee; Aaron W James Abstract Transcriptional factor regulation is central to the lineage commitment of stem/ progenitor cells...

... may occur at the hematopoietic stem and progenitor cells (HSPCs) level to elicit hematopoietic changes. However, our understanding of the underlying molecular mechanisms remains incomplete. Here, we characterize the transcriptional and chromatin accessibility landscapes of bone marrow and splenic...

... decreased transcription of the global plasmid regulators (korA, korB, and korC) and numerous genes in their regulons. This is consistent with our findings that Upf31 represses its own transcription. It also caused secondary transcriptional changes in many chromosomal genes...

... While most ATRTs share the feature of SMARCB1 loss and genomic stability, at least three major molecular subgroups of SMARCB1-altered ATRT exist (ATRT-MYC, ATRT-TYR and ATRT-SHH).25,26 As the cell lines used in the above analyses transcriptionally classify as ATRTMYC (see Methods), we further assessed...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Cells respond to many different types of stresses by overhauling gene expression patterns, both at the transcriptional and translational levels. Under...