.... Bulk mRNA-seq analysis showed that GSC005 tumors in NSG mice displayed an upregulated mesenchymal signature, characterized by epithelial-to-mesenchymal transition (EMT), and downregulation of type-I and type-II interferon signaling. Our data further suggests that host-intrinsic and therapeutic type-I...

...-19 shifted cooking behaviors and exacerbated preexisting gender disparities in frequency of cooking meals at home. Future research is needed to better understand the role of cooking behaviors in the nutrition transition at global, national, and local levels. food systems eating practices gender...

... on behalf of the Endocrine Society 2025. 2025 This work is written by (a) US Government employee(s) and is in the public domain in the US. See the journal About page for additional terms. Abstract Introduction Transitioning from pediatric to adult-centered diabetes care may be challenging, especially...

... was significantly different from the stimulation of Brownian motion or phylogenetic randomness. To investigate pattern transitions in Pachyrhynchus weevils, we used the multistate function in BayesTraits v.4.0.0 to assess the transition relationships among the six pattern categories...

... disparities. Transition-aged youth with type 1 diabetes (T1D) represent a vulnerable population; not enough attention is given to their inclusion in behavioral health interventions. Behavioral Family Systems Therapy for Diabetes Transition (BFST-DT) is an intervention aimed at improving transition readiness...

... hormone therapy (GAHT), is part of the transition for many transgender and nonbinary (TGNB) individuals; however, there have been few studies investigating sexual function and desire during GAMT, and no reports on individuals who received PB. Aim We aimed to qualitatively evaluate the sexual...

..., Mexican Transition Zone Accepted Manuscript Introduction The Mexican Transition Zone is characterized by the confluence of five physiographic units through Nicaragua, El Salvador, Honduras, Guatemala, and Mexico (Morrone, 2020). The mountain systems that conform the Mexican Transition Zone correspond...

... University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Purpose This case series explores the use of thrombin time (TT) to transition 2 patients from dabigatran to unfractionated heparin (UFH) in the setting of acute kidney injury...

..., Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) anticoagulation stewardship direct oral anticoagulants education oral anticoagulants transition of care warfarin Clinicians utilize oral anticoagulants (OACs) to treat thromboembolic conditions...

... conformation due to its lower energy state, thus inducing an inevitable conformational transition process. This process further leads to dynamic changes of important material features, such as the hydrogel pore size and mechanical properties, which can probably bring some non-negligible and unknown impacts...

... the dynamics of the gender pay gap (GPG) in two post-socialist economies, Czechia and Slovenia, during their capitalist transition and EU membership. Using regression analysis on large samples of linked employer–employee data to estimate the total GPG and within-job GPG and institutional analysis, we find...

... representation to advance women’s political rights. Moving beyond institutional variables in mainstream political science, it employs the theory-guided process-tracing method to explore how democratic transitions shape the relationship between feminist movements, political parties, legislatures, and the state...

... processes involved in this transition in Mexico, focusing on how the adoption of a rights-based strategy shaped the feminist cultural struggle and the reframing of the abortion issue. The study also addresses the link between framing and the movement’s organizational structure, arguing that the central...

... the carbon emission sequences at different times. The state transition state of the Markov process is determined by dividing the relative error of gray prediction results. Calculate the carbon emission prediction value, and take the arithmetic average as the final carbon emission prediction result...

... algorithms to identify the genetic underpinnings (i.e. core gene sets) driving the transition from normal breast tissue into a tumor state, which can help with cancer diagnostics, prognostics, and treatment solutions. Fortunately, deep learning models transform complex perturbational phenomena...

... records through 2022 to identify deaths occurring age 16-23. We defined three care statuses: pretransition, transition, and posttransition. Pretransition was age 16 to the last day of care. Transition was the first 120 days after exiting care. Posttransition was all days after transition. We calculated...

... on our site—for further information please contact [email protected]. In this study, care transitions specifically refer to moves into and between social care services, such as care homes or extra care housing. These transitions are significant life events for many older people...

... the A-ring was replaced with a benzene ring, in 6 steps from commercially available 2-methyl-1-tetralone. Similarly to vitetrifolin D, this analog suppressed the phorbol ester–induced epithelial-mesenchymal transition. This tetralone-based structural simplification strategy is expected to be applicable...

... Intestinal tissues were procured from 28 patients diagnosed with CD and 8 healthy control subjects. Histological and immunofluorescence assays verified that PIEZO1 is substantially overexpressed in fibrotic intestinal tissues and is involved in epithelial‒mesenchymal transition (EMT). Further gene knockout...

... factor PROP1 are the most common, known cause of hypopituitarism in humans. Prop1 is the first pituitary-specific gene in the hierarchy of transcription factors that regulate pituitary development. It is essential for regulating the transition of pituitary stem cells to hormone-producing cells...