Meeting Cluster Issue: Brazilian Society of Immunology 2023

Mild to severe COVID-19, but not other respiratory infections, increased cellular senescence and exhaustion in CD4 and CD8 T cells over a 7-d period of infection.

Diet-induced obesity impacts the macrophages’ function in vitro and in vivo and favors Leishmania major infection in C57BL/6 mice.

Lipid droplets regulate cellular lipid, energy balance, signaling, and inflammatory mediator production, impacting SARS-CoV-2 infection. Their accumulation suggests a dual role in viral replication and inflammation, highlighting therapeutic opportunities.

Efflux pump outer membrane proteins, involved in antimicrobial resistance, are interesting vaccine candidates against clinically relevant multidrug-resistant Gram-negative bacteria, but it is important to consider potential effects on microbiota.

Our findings suggest that lipid droplet biogenesis in Listeria monocytogenes–infected macrophages plays a key role in bacterial pathogenesis, bacterial survival, and regulation of innate immunity.