Volume 96, Issue 2, Aug 2014

Discussion on activation of macrophage transcriptional networks during inflammation.

Discussion on how pro-MMP-9 has both stimulatory and inhibitory actions on tumor B cell motility, thus modulating homing to lymphoid tissues.

Analysis of transcriptomics data reveals the LPS response can be subdivided into a larger number of co-regulated gene subsets than previously considered.

Elevated (pro)MMP-9 expression alters key regulatory molecules (ERK, FAK, RhoAGTPase, PTEN) and impairs CLL cell migration, favoring organ retention and disease progression.

Basic Research for Clinicians: Molecular and cellular mechanisms of H. pylori-induced inflammation, oxidative stress, DNA damage, and gastric carcinogenesis; implications for clinical research and chemoprevention.

Clinical Review for Basic Researchers: Clinical trials related to H. pylori-associated gastric carcinogenesis and gastric cancer prevention efforts highlighting opportunities for basic research.

Review on histamine as a relevant player in the generation and maintenance of tumors and anti-tumor responses.

Review of how cells can sense their own infection, and their attempts to eliminate pathogens.

Early age-related changes in specific DC populations during priming can contribute to impaired Th1 differentiation.

HCV induces the upregulation of SOCS3 protein, which blocks TNF-α-mediated signal transduction, directly regulating induction of proinflammatory cytokines.

Prolonged anti-CSF1R prevents age-dependent bone loss in female mice, without the phenotypic consequences of the CSF1R and CSF1 null mutations.

FcγRI (CD64) mediates the inhibitory effects of cross-linked IgG on murine fibrocytes.

Oxidative stress enhances dendritic cells' capability of inducing CD4⁺ T cell proliferation and production of proinflammatory cytokines and PI3Kγ-dependent migration, but reduces generation of T-regulatory cells.

IL-10-producing CD14⁺ immunomodulatory monocytes are induced through human MSC-secreted HGF via ERK1/2 to modulate allogeneic T cell function.

Hypoxia and HIF-1α substantially influence human T cell mediated immune responses by direct modulation of nTreg and Th-17 functions.

Differential regulation of IL-12 family members in DCs in response to apoptotic or necrotic cell uptake.

Leishmanial lipid as a strong protective agent against bacterial endotoxin-induced inflammatory responses in vitro, and in murine systems toward organ injury.

a2V protein is indispensable for the regulation of macrophages and cytokine/chemokine balance in the testis during normal spermatogenesis.

B cells promote bone loss and inflammation in obesity-associated periodontitis, but play a modest role in periodontitis of lean hosts.