Cover image
On the cover: The transcriptional response of splenic murine B cells to IFN-α stimulation, projected on a 2D space. All cells (dots) follow the same inferred trajectory (arrows), from no stimulation (purple) to one (blue), two (green) and three (yellow) hours post simulation. Fewer female cells at transitional states suggest faster activation. Gal-Oz, S.T., A. Baysoy, B. Vijaykumar, S. Mostafavi, C. Benoist, T. Shay, and the Immunological Genome Project. 2024. Microheterogeneity in the kinetics and sex-specific response to type IIFN. J. Immunol. 213: 96–104.
Volume 213, Issue 1, July 2024
Top Reads
Top Reads
Pillars of Immunology
NKT Cells and Other Innate T Cells: The Immune Cells That Do Not Follow the Rules
Cutting Edge
Cutting Edge: LAG3 Dimerization Is Required for TCR/CD3 Interaction and Inhibition of Antitumor Immunity
LAG3 monomers are unable to associate with the TCR/CD3 complex on CD8+ T cells.
LAG3 monomers are unable to limit the antitumor activity of CD8+ T cells in a mouse model of melanoma.
The anti-LAG3 Ab C9B7W disrupts dimerization of LAG3 and its association with the TCR/CD3 complex.
Autoimmunity
A Targeted Deep Sequencing Method to Quantify Endogenous Retrovirus Gag Sequence Variants and Open Reading Frames Expressed in Nonobese Diabetic Mice
Gag gene sequence variants are associated with the autoimmune response.
An increase in ORFs positively correlates with disease progression.
Specific amino acid residues of the Gag variants are associated with T1D.
Clinical and Human Immunology
Effect of HLA Genotype on Anti-PD-1 Antibody Treatment for Advanced Renal Cell Carcinoma in the SNiP-RCC Study
High HED at the HLA-B enhances anti-tumor effect of nivolumab in advanced RCC.
The Immunogenomic Landscape of Peripheral High-Dose IL-2 Pharmacodynamics in Patients with Metastatic Renal Cell Carcinoma: A Benchmark for Next-Generation IL-2–Based Immunotherapies
HD IL-2 promotes effector lymphocytes (CD8+ and NK cells) extravasation and expansion.
B cells undergo oligoclonal expansion during HD IL-2 therapy.
Treg expansion is associated with myeloid suppression post-HD IL-2 therapy.
Replication Stress in Activated Human NK Cells Induces Sensitivity to Apoptosis
NK cells are more sensitive to replication stress, resulting in apoptosis.
Helicase deficiency is linked to replication stress and impaired NK cell function.
Immune Regulation
SKI Regulates Medullary Thymic Epithelial Cell Differentiation to Control Peripheral T Cell Responses in Mice
TECs require SKI expression for normal thymic medulla development and function.
Splenic CD4+ T cell proliferation is reduced from Foxn1Cre+/−SKIfl/fl mice in vitro.
Foxn1Cre+/−SKIfl/fl mice exhibited reduced EAE disease severity.
A Negative Regulatory Feedback Loop within the JAK–STAT Pathway Mediated by the Protein Tyrosine Phosphatase DUSP14 in Shrimp
This study identifies the novel dual-specificity protein phosphatase PvDUSP14 from shrimp.
PvDUSP14 mediates a negative feedback regulatory loop in the JAK–STAT pathway.
PvDUSP14 modulates homeostasis of JAK–STAT signaling and is involved in immune response.
Innate Immunity and Inflammation
Neutrophil-Derived Peptidyl Arginine Deiminase Activity Contributes to Pulmonary Emphysema by Enhancing Elastin Degradation
PAD enzymes and citrullinated proteins are present in COPD airways.
Citrullinated elastin is susceptible to proteolytic degradation.
CANE, a Component of the NLRP3 Inflammasome, Promotes Inflammasome Activation
CANE is a component of the NLRP3 inflammasome.
CANE modulates activation of the NLRP3 inflammasome.
CANE-transgenic mice have a skin-involved CAPS-like phenotype.
Systems Immunology
Microheterogeneity in the Kinetics and Sex-Specific Response to Type I IFN
IFN response of the immune cell population reflects homogeneous response of single cells.
Immune cell types differ in responding cells’ fraction and response rate.
Female cells respond faster than male cells in the three cell types tested.
