Volume 208, Issue 8, April 2022

Loss of ST8Sia6 in mice reduces tumor growth.

Loss of ST8Sia6 increases inflammatory factors in macrophages and dendritic cells.

Loss of ST8Sia6 in APCs is responsible for enhanced antitumor response.

HLA-A2–bound 20mer peptide contains C-terminal peptide tail hanging from HLA-I cleft.

C-terminal tail of this 20mer peptide can play a critical role in T cell recognition.

SARS-CoV-2 particle/protein exposure induces monocyte activation during pregnancy.

SARS-CoV-2 protein exposure mildly enhances T cell activation during pregnancy.

SARS-CoV-2 challenge triggers pregnancy-specific cytokine responses in the mother.

Utx and Jmjd3 deletion leads to an increase in plasma cells poststimulation.

UTX/JMJD3 regulate cell growth, oxidative phosphorylation, and cell death genes.

UTX/JMJD3 alter chromatin accessibility at ETS and IRF motifs.

lincRNA-Cox2 is highly expressed in the lung and most inducible in AMs after LPS.

We show lincRNA-Cox2 functions in trans to regulate gene expression after ALI.

lincRNA-Cox2’s function is mediated by BM-derived cells, likely infiltrating AMs.

During influenza infection, bystander memory CD8⁺ T cells are activated.

The IFN-induced gene signature is upregulated in bystander-activated CD8⁺ T cells.

IFITM3 distinguishes bystander activation from TCR-dependently activated T cells.

PGE₂-EP4 signal is essential for IgM response to TI Ags.

PGE₂-EP4 provides an unrecognized link between ER stress response and SLPC life span.

PGE₂’s support of SLPC survival is vital for the immune protection against bacteria.

Mettl14-mediated m6A controls the GC reaction and Ab response.

Mettl14 regulates Ythdf2-dependent but Myc-independent positive selection of the GC.

m6A modification promotes mRNA degradation of negative immune regulators.

SATB1 expression increases in naive B cells and decreases upon BCR activation.

SATB1 has roles in the growth and maturation of naive B cells upon BCR activation.

SATB1 supports the survival of naive B cells by regulating antiapoptotic genes.

Neonatal alveolar macrophages express a proinflammatory expression signature.

Neonatal and adult alveolar macrophages respond similarly to inhaled LPS.

Unique features of alveolar macrophages are lost upon removal from the lung.

Squamate reptiles, the lizards and snakes, have lost the γδ T cell lineage.

The loss is due to genomic deletions of the genes encoding TCRγ and TCRδ.

Squamates are a natural knockout of a major, but enigmatic, T cell lineage.

Expressions of many inflammation-related genes are altered in COVID-19 patients.

Some of these changes correlate with their histone methylation marks.

Drosophila lncRNA-CR33942 is mainly expressed in the nucleus.

lncRNA-CR33942 enhances Toll immune responses and the survival of Drosophila.

lncRNA-CR33942 facilitates antimicrobial peptide transcriptions via interacting with Dif/Dorsal.

Neurotropic coronavirus-specific Tregs persist after infection as memory cells.

Memory Tregs are better able to proliferate than naive counterparts.

Memory Tregs better inhibit effector T cell responses in the CNS than do naive Tregs.

T-bet and Eomes conjointly repress Th17 development during influenza infection.

Th17 effectors that cannot gain Th1 functionality in vivo protect against influenza.

Mice lacking T-bet and Eomes survive primary and heterosubtypic influenza infection.

Deletion of IL-27RA confers susceptibility to primary hookworm lung infection.

Recombinant IL-27 treatment reduces lung parasite burden and injury in mice.

IL-27 promotes antihelminthic responses via IL-27RA⁺ γδ T cells in the lungs.

Stroke-associated lung infection increases with advanced age.

Stroke accentuates the age-dependent impairment of neutrophil function.

The NEK7 catalytic domain is required for NLRP3 activation.

A single residue differentiates between NEK7 and NEK6 in NLRP3 activation.

A NEK7 structural pocket is essential for NLRP3 activation.

LECT2 is a novel antibacterial protein in vertebrates.

LECT2 is a bifunctional protein with bactericidal and immunoregulatory activities.

Two LECT2 genes exist in teleost fish with one specialized in mucosal immunity.

CD4⁺ T cells infiltrate into the brain during chronic colitis.

Brain-infiltrating CD4⁺ T cells causing neuropathology resemble pathogenic Th17 cells.

In the absence of RORγt, CD4⁺ T cells fail to infiltrate into the brain.

Riplet is expressed in T cells and upregulated in activated CD8⁺ T cells.

Riplet regulates the effector function of CD8⁺ T cells via TCR stimulation.

Riplet suppresses the T cell–mediated antitumor immune response.