Volume 196, Issue 2
January 2016
Cover image
Cover image
On the cover: Confocal microscopy image of co-localization of PIAS3 (green) and Rac1 (red) in ruffling lamellipodia at the leading edge of migrating fibroblast-like synoviocytes from patients with rheumatoid arthritis, detecting by immunofluorescence double staining. Original magnification ×400. Minxi, L., M. Shi, Y. Zou, M. Huang, Y. Ye, Q. Qiu, Y. Xiao, S. Zeng, L. Liang, X. Yang, and H. Xu. 2016. Protein inhibitor of activated STAT3 regulates migration, invasion, and activation of fibroblast-like synoviocytes in rheumatoid arthritis. J. Immunol. 196: 596–606.
ISSN 0022-1767
EISSN 1550-6606
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Volume 196, Issue 2, January 2016
In this Issue
In This Issue
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 519–520, https://doi.org/10.4049/jimmunol.1590027
Letters to the Editor
Comment on Three X-ray Crystal Structure Papers
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 521–524, https://doi.org/10.4049/jimmunol.1501343
Comments from the Editor-in-Chief
The Journal of Immunology, Volume 196, Issue 2, January 2016, Page 521, https://doi.org/10.4049/jimmunol.1502280
Response to Comment on Three X-ray Crystal Structure Papers
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 524–528, https://doi.org/10.4049/jimmunol.1501474
Additional Comment on Three X-ray Crystal Structure Papers
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 528–530, https://doi.org/10.4049/jimmunol.1502281
Comment on “Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice”
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 530–531, https://doi.org/10.4049/jimmunol.1502255
Response to Additional Comment on Three X-ray Crystal Structure Papers
The Journal of Immunology, Volume 196, Issue 2, January 2016, Page 530, https://doi.org/10.4049/jimmunol.1502468
Response to Comment on “Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice”
The Journal of Immunology, Volume 196, Issue 2, January 2016, Page 531, https://doi.org/10.4049/jimmunol.1502300
Brief Reviews
Posttranscriptional and Translational Control of Gene Regulation in CD4+ T Cell Subsets
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 533–540, https://doi.org/10.4049/jimmunol.1501337
Cutting Edge
Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 543–546, https://doi.org/10.4049/jimmunol.1502080
Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 547–552, https://doi.org/10.4049/jimmunol.1501415
Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 553–557, https://doi.org/10.4049/jimmunol.1403042
Cutting Edge: Ezrin Regulates Inflammation by Limiting B Cell IL-10 Production
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 558–562, https://doi.org/10.4049/jimmunol.1502098
Autoimmunity
SATB1 Plays a Critical Role in Establishment of Immune Tolerance
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 563–572, https://doi.org/10.4049/jimmunol.1501429
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 573–585, https://doi.org/10.4049/jimmunol.1501406
Clinical and Human Immunology
Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 586–595, https://doi.org/10.4049/jimmunol.1500630
Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 596–606, https://doi.org/10.4049/jimmunol.1403254
IgG1 Allotypes Influence the Pharmacokinetics of Therapeutic Monoclonal Antibodies through FcRn Binding
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 607–613, https://doi.org/10.4049/jimmunol.1501780
The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 614–623, https://doi.org/10.4049/jimmunol.1500355
Immune Regulation
Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 624–636, https://doi.org/10.4049/jimmunol.1501202
Norepinephrine Controls Effector T Cell Differentiation through β2-Adrenergic Receptor–Mediated Inhibition of NF-κB and AP-1 in Dendritic Cells
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 637–644, https://doi.org/10.4049/jimmunol.1501206
Differential Responsiveness of Innate-like IL-17– and IFN-γ–Producing γδ T Cells to Homeostatic Cytokines
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 645–654, https://doi.org/10.4049/jimmunol.1502082
Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 655–667, https://doi.org/10.4049/jimmunol.1501708
Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 668–677, https://doi.org/10.4049/jimmunol.1501888
Regulatory T Cells Orchestrate Similar Immune Evasion of Fetuses and Tumors in Mice
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 678–690, https://doi.org/10.4049/jimmunol.1501834
Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 691–702, https://doi.org/10.4049/jimmunol.1500710
Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 703–714, https://doi.org/10.4049/jimmunol.1501820
Dynamic Regulation of Tandem 3′ Untranslated Regions in Zebrafish Spleen Cells during Immune Response
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 715–725, https://doi.org/10.4049/jimmunol.1500847
Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 726–737, https://doi.org/10.4049/jimmunol.1501266
Immune System Development
TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 738–749, https://doi.org/10.4049/jimmunol.1501729
Immunogenetics
Complex MHC Class I Gene Transcription Profiles and Their Functional Impact in Orangutans
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 750–758, https://doi.org/10.4049/jimmunol.1500820
Immunotherapy and Vaccines
Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 759–766, https://doi.org/10.4049/jimmunol.1401710
Infectious Disease and Host Response
Beneficial Effects of CpG-Oligodeoxynucleotide Treatment on Trauma and Secondary Lung Infection
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 767–777, https://doi.org/10.4049/jimmunol.1500597
The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 778–791, https://doi.org/10.4049/jimmunol.1403206
Salmonella Virulence Factor SsrAB Regulated Factor Modulates Inflammatory Responses by Enhancing the Activation of NF-κB Signaling Pathway
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 792–802, https://doi.org/10.4049/jimmunol.1500679
IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 803–812, https://doi.org/10.4049/jimmunol.1500705
Innate Immunity and Inflammation
Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 813–822, https://doi.org/10.4049/jimmunol.1502009
Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 823–831, https://doi.org/10.4049/jimmunol.1501080
TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 832–845, https://doi.org/10.4049/jimmunol.1500960
Activator of G-Protein Signaling 3–Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 846–856, https://doi.org/10.4049/jimmunol.1501595
MASP-1 and MASP-2 Do Not Activate Pro–Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 857–865, https://doi.org/10.4049/jimmunol.1501717
Molecular and Structural Immunology
Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 866–876, https://doi.org/10.4049/jimmunol.1501919
Transplantation
IL-12–Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 877–890, https://doi.org/10.4049/jimmunol.1501589
Tumor Immunology
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 891–901, https://doi.org/10.4049/jimmunol.1501648
The Fractalkine-Receptor Axis Improves Human Colorectal Cancer Prognosis by Limiting Tumor Metastatic Dissemination
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 902–914, https://doi.org/10.4049/jimmunol.1501335
Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 915–923, https://doi.org/10.4049/jimmunol.1500729
Novel Immunological Methods
Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding
The Journal of Immunology, Volume 196, Issue 2, January 2016, Pages 924–932, https://doi.org/10.4049/jimmunol.1501928
