Volume 191, Issue 6
September 2013
Cover image
Cover image
On the cover: Overexpression of RIG-I fails to suppress HBV replication in Huh7 cells. Huh7 cells were cotransfected with RIG-I expression plasmid and the HBV replicative plasmid. The confocal microscopic image shows that cells with RIG-I expression (red) are also positive for HBV core Ag (green), indicating that RIG-I signaling fails to suppress HBV replication. Lu, H.-L., and F. Liao. 2013. Melanoma differentiation–associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication. J. Immunol. 191: 3264–3276.
ISSN 0022-1767
EISSN 1550-6606
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Volume 191, Issue 6, September 2013
In Memoriam
Leo Lefrançois, Jr., Ph.D. (AAI ’84) 1956–2013: A Stunning Loss and a Lasting Legacy
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2853–2854, https://doi.org/10.4049/jimmunol.1390049
In This Issue
In This Issue
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2855–2856, https://doi.org/10.4049/jimmunol.1390047
Brief Reviews
Processes of Sterile Inflammation
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2857–2863, https://doi.org/10.4049/jimmunol.1301539
Cutting Edge
Cutting Edge: Ly49C/I− Neonatal NK Cells Predispose Newborns to Autoimmune Ovarian Disease Induced by Maternal Autoantibody
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2865–2869, https://doi.org/10.4049/jimmunol.1301500
Allergy and Other Hypersensitivities
The Tetraspanin CD63 Is Required for Efficient IgE-Mediated Mast Cell Degranulation and Anaphylaxis
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2871–2878, https://doi.org/10.4049/jimmunol.1202323
Alendronate Attenuates Eosinophilic Airway Inflammation Associated with Suppression of Th2 Cytokines, Th17 Cytokines, and Eotaxin-2
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2879–2889, https://doi.org/10.4049/jimmunol.1300460
Establishment of a Human Allergy Model Using Human IL-3/GM-CSF–Transgenic NOG Mice
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2890–2899, https://doi.org/10.4049/jimmunol.1203543
Human Airway Eosinophils Exhibit Preferential Reduction in STAT Signaling Capacity and Increased CISH Expression
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2900–2906, https://doi.org/10.4049/jimmunol.1300297
Antigen Recognition and Responses
Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2907–2915, https://doi.org/10.4049/jimmunol.1301195
Enhanced TCR Footprint by a Novel Glycolipid Increases NKT-Dependent Tumor Protection
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2916–2925, https://doi.org/10.4049/jimmunol.1203134
Autoimmunity
TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2926–2937, https://doi.org/10.4049/jimmunol.1300547
Targeting of Autoantigens to DEC205+ Dendritic Cells In Vivo Suppresses Experimental Allergic Encephalomyelitis in Mice
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2938–2947, https://doi.org/10.4049/jimmunol.1202592
The Cellular Source and Target of IL-21 in K/BxN Autoimmune Arthritis
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2948–2955, https://doi.org/10.4049/jimmunol.1301173
A Synthetic TLR3 Ligand Mitigates Profibrotic Fibroblast Responses by Inducing Autocrine IFN Signaling
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2956–2966, https://doi.org/10.4049/jimmunol.1300376
The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2967–2977, https://doi.org/10.4049/jimmunol.1300419
B Cells, Dendritic Cells, and Macrophages Are Required To Induce an Autoreactive CD4 Helper T Cell Response in Experimental Epidermolysis Bullosa Acquisita
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2978–2988, https://doi.org/10.4049/jimmunol.1300310
Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56dim NK Cells
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2989–2998, https://doi.org/10.4049/jimmunol.1301022
Clinical and Human Immunology
Neuromyelitis Optica IgG Causes Placental Inflammation and Fetal Death
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 2999–3005, https://doi.org/10.4049/jimmunol.1301483
Characterization of Resident B Cells of Vascular Walls in Human Atherosclerotic Patients
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3006–3016, https://doi.org/10.4049/jimmunol.1202870
Immune Regulation
Transcriptional Regulation of IL-15 Expression during Hematopoiesis
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3017–3024, https://doi.org/10.4049/jimmunol.1301389
CD8+ T Cells Produce the Chemokine CXCL10 in Response to CD27/CD70 Costimulation To Promote Generation of the CD8+ Effector T Cell Pool
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3025–3036, https://doi.org/10.4049/jimmunol.1202222
MiR-210 Is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3037–3048, https://doi.org/10.4049/jimmunol.1301289
Dermal Regulatory T Cells Display Distinct Migratory Behavior That Is Modulated during Adaptive and Innate Inflammation
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3049–3056, https://doi.org/10.4049/jimmunol.1203205
IDO1 Plays an Immunosuppressive Role in 2,4,6-Trinitrobenzene Sulfate–Induced Colitis in Mice
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3057–3064, https://doi.org/10.4049/jimmunol.1203306
Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-like Skin Inflammation
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3065–3072, https://doi.org/10.4049/jimmunol.1300348
CD28 Sensitizes TCR Ca2+ Signaling during Ag-Independent Polarization of Plasma Membrane Rafts
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3073–3081, https://doi.org/10.4049/jimmunol.1300485
CTLA4Ig Inhibits Effector T Cells through Regulatory T Cells and TGF-β
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3082–3089, https://doi.org/10.4049/jimmunol.1300830
Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3090–3099, https://doi.org/10.4049/jimmunol.1300772
T Cell–Derived IL-17 Mediates Epithelial Changes in the Airway and Drives Pulmonary Neutrophilia
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3100–3111, https://doi.org/10.4049/jimmunol.1301360
Reduced T-Dependent Humoral Immunity in CD20-Deficient Mice
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3112–3118, https://doi.org/10.4049/jimmunol.1202098
CCR7 Plays No Appreciable Role in Trafficking of Central Memory CD4 T Cells to Lymph Nodes
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3119–3127, https://doi.org/10.4049/jimmunol.1200938
Plasma Cell Homeostasis: The Effects of Chronic Antigen Stimulation and Inflammation
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3128–3138, https://doi.org/10.4049/jimmunol.1301163
IL-4 and Retinoic Acid Synergistically Induce Regulatory Dendritic Cells Expressing Aldh1a2
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3139–3151, https://doi.org/10.4049/jimmunol.1300329
Human CD1c+ Myeloid Dendritic Cells Acquire a High Level of Retinoic Acid–Producing Capacity in Response to Vitamin D3
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3152–3160, https://doi.org/10.4049/jimmunol.1203517
IL-7 Modulates In Vitro and In Vivo Human Memory T Regulatory Cell Functions through the CD39/ATP Axis
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3161–3168, https://doi.org/10.4049/jimmunol.1203547
B Cell–Intrinsic and –Extrinsic Regulation of Antibody Responses by PARP14, an Intracellular (ADP-Ribosyl)Transferase
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3169–3178, https://doi.org/10.4049/jimmunol.1301106
Immune System Development
B Cells from Knock-in Mice Expressing Broadly Neutralizing HIV Antibody b12 Carry an Innocuous B Cell Receptor Responsive to HIV Vaccine Candidates
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3179–3185, https://doi.org/10.4049/jimmunol.1301283
Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3186–3191, https://doi.org/10.4049/jimmunol.1301285
Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF in Humanized Mice
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3192–3199, https://doi.org/10.4049/jimmunol.1300742
Parental Dietary Fat Intake Alters Offspring Microbiome and Immunity
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3200–3209, https://doi.org/10.4049/jimmunol.1301057
Phosphatase Wip1 Is Essential for the Maturation and Homeostasis of Medullary Thymic Epithelial Cells in Mice
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3210–3220, https://doi.org/10.4049/jimmunol.1300363
Immunotherapy and Vaccines
DNA Vaccine that Targets Hemagglutinin to MHC Class II Molecules Rapidly Induces Antibody-Mediated Protection against Influenza
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3221–3231, https://doi.org/10.4049/jimmunol.1300504
Blockade of TGF-β Signaling Greatly Enhances the Efficacy of TCR Gene Therapy of Cancer
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3232–3239, https://doi.org/10.4049/jimmunol.1301270
Guanine Modification of Inhibitory Oligonucleotides Potentiates Their Suppressive Function
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3240–3253, https://doi.org/10.4049/jimmunol.1300706
Infectious Disease and Host Response
Noncovalent Association of Protein and Capsular Polysaccharide on Bacteria-Sized Latex Beads as a Model for Polysaccharide-Specific Humoral Immunity to Intact Gram-Positive Extracellular Bacteria
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3254–3263, https://doi.org/10.4049/jimmunol.1300722
Melanoma Differentiation–Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling To Suppress Virus Replication
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3264–3276, https://doi.org/10.4049/jimmunol.1300512
The Rate of Immune Escape Vanishes When Multiple Immune Responses Control an HIV Infection
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3277–3286, https://doi.org/10.4049/jimmunol.1300962
Identification of a Phage-Encoded Ig-Binding Protein from Invasive Neisseria meningitidis
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3287–3296, https://doi.org/10.4049/jimmunol.1301153
Persistence of the Bacterial Pathogen Granulibacter bethesdensis in Chronic Granulomatous Disease Monocytes and Macrophages Lacking a Functional NADPH Oxidase
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3297–3307, https://doi.org/10.4049/jimmunol.1300200
Hepatitis C Virus–Infected Cells Downregulate NKp30 and Inhibit Ex Vivo NK Cell Functions
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3308–3318, https://doi.org/10.4049/jimmunol.1300164
Innate Immunity and Inflammation
Human SAP Is a Novel Peptidoglycan Recognition Protein That Induces Complement-Independent Phagocytosis of Staphylococcus aureus
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3319–3327, https://doi.org/10.4049/jimmunol.1300940
Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3328–3336, https://doi.org/10.4049/jimmunol.1300225
Toll IL-1R8/Single Ig IL-1–Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by γδ T Cells
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3337–3346, https://doi.org/10.4049/jimmunol.1300828
Contributions of the Three CYP1 Monooxygenases to Pro-Inflammatory and Inflammation-Resolution Lipid Mediator Pathways
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3347–3357, https://doi.org/10.4049/jimmunol.1300699
Resident Renal Mononuclear Phagocytes Comprise Five Discrete Populations with Distinct Phenotypes and Functions
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3358–3372, https://doi.org/10.4049/jimmunol.1300342
Apoptosis-Associated Speck–like Protein Containing a Caspase Recruitment Domain Inflammasomes Mediate IL-1β Response and Host Resistance to Trypanosoma cruzi Infection
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3373–3383, https://doi.org/10.4049/jimmunol.1203293
Type I IFNs Downregulate Myeloid Cell IFN-γ Receptor by Inducing Recruitment of an Early Growth Response 3/NGFI-A Binding Protein 1 Complex That Silences ifngr1 Transcription
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3384–3392, https://doi.org/10.4049/jimmunol.1203510
Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3393–3399, https://doi.org/10.4049/jimmunol.1300740
Morphine Prevents Lipopolysaccharide-Induced TNF Secretion in Mast Cells Blocking IκB Kinase Activation and SNAP-23 Phosphorylation: Correlation with the Formation of a β-Arrestin/TRAF6 Complex
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3400–3409, https://doi.org/10.4049/jimmunol.1202658
Molecular and Structural Immunology
Shark IgW C Region Diversification through RNA Processing and Isotype Switching
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3410–3418, https://doi.org/10.4049/jimmunol.1301257
Global DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3419–3429, https://doi.org/10.4049/jimmunol.1301395
Mucosal Immunology
CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Responses and Genital Tract Inflammation upon Intracellular Chlamydia muridarum Infection
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3430–3439, https://doi.org/10.4049/jimmunol.1301136
Transplantation
Vascular Endothelial Growth Factor-D–Mediated Blockade of Regulatory T Cells within Tumors Is Induced by Hematopoietic Stem Cell Transplantation
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3440–3452, https://doi.org/10.4049/jimmunol.1201454
Tumor Immunology
Innate Immune Cell–Derived Microparticles Facilitate Hepatocarcinoma Metastasis by Transferring Integrin αMβ2 to Tumor Cells
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3453–3461, https://doi.org/10.4049/jimmunol.1300171
Expression of Leukotriene B4 Receptor-1 on CD8+ T Cells Is Required for Their Migration into Tumors To Elicit Effective Antitumor Immunity
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3462–3470, https://doi.org/10.4049/jimmunol.1300967
Death Receptor–Independent Activation-Induced Cell Death in Human Melanoma Antigen–Specific MHC Class I–Restricted TCR-Engineered CD4 T Cells
The Journal of Immunology, Volume 191, Issue 6, September 2013, Pages 3471–3477, https://doi.org/10.4049/jimmunol.1202350
Corrections
Correction: CCR5 Blockade in Combination With Cyclosporine Increased Cardiac Graft Survival and Generated Alternatively Activated Macrophages in Primates
The Journal of Immunology, Volume 191, Issue 6, September 2013, Page 3478, https://doi.org/10.4049/jimmunol.1390046
