Volume 188, Issue 4
February 2012
Cover image
Cover image
On the cover: Ischemic injury to murine kidney induces upregulation of TLR-4 (stained red) in proximal renal tubular cells and in pericapillary endothelial cells (anti-CD31, stained green). TLR-4 expression after 3 h of reperfusion is depicted. TLR-4 in endothelial cells stains yellow, indicating colocalization with the green-stained endothelial cell CD31 marker. Lobo, P. I., A. Bajwa, K. H. Schlegel, J. Vengal, S. J. Lee, L. Huang, H. Ye, U. Deshmukh, T. Wang, H. Pei, and M. D. Okusa. 2012. Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17. J. Immunol. 188: 1675–1685.
ISSN 0022-1767
EISSN 1550-6606
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Volume 188, Issue 4, February 2012
In this Issue
In This Issue
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1571–1572, https://doi.org/10.4049/jimmunol.1190090
Cutting Edge
Cutting Edge: A Variant of the IL-23R Gene Associated with Inflammatory Bowel Disease Induces Loss of MicroRNA Regulation and Enhanced Protein Production
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1573–1577, https://doi.org/10.4049/jimmunol.1101494
Cutting Edge: IL-21 Derived from Human Follicular Helper T Cells Acts as a Survival Factor for Secondary Lymphoid Organ, but Not for Bone Marrow, Plasma Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1578–1581, https://doi.org/10.4049/jimmunol.1102786
Cellular Immunology and Immune Regulation
TRAIL+ Human Plasmacytoid Dendritic Cells Kill Tumor Cells In Vitro: Mechanisms of Imiquimod- and IFN-α–Mediated Antitumor Reactivity
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1583–1591, https://doi.org/10.4049/jimmunol.1102437
Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1592–1599, https://doi.org/10.4049/jimmunol.1101304
Temporal Predisposition to αβ and γδ T Cell Fates in the Thymus
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1600–1608, https://doi.org/10.4049/jimmunol.1102531
IL-21 Can Supplement Suboptimal Lck-Independent MAPK Activation in a STAT-3–Dependent Manner in Human CD8+ T Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1609–1619, https://doi.org/10.4049/jimmunol.1003446
IL-2 Upregulates CD86 Expression on Human CD4+ and CD8+ T Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1620–1629, https://doi.org/10.4049/jimmunol.1100181
Th2 Skewing by Activation of Nrf2 in CD4+ T Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1630–1637, https://doi.org/10.4049/jimmunol.1101712
PSGL-1 Regulates the Migration and Proliferation of CD8+ T Cells under Homeostatic Conditions
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1638–1646, https://doi.org/10.4049/jimmunol.1103026
OX40 Ligand and Programmed Cell Death 1 Ligand 2 Expression on Inflammatory Dendritic Cells Regulates CD4 T Cell Cytokine Production in the Lung during Viral Disease
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1647–1655, https://doi.org/10.4049/jimmunol.1103001
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1656–1667, https://doi.org/10.4049/jimmunol.1003871
Human NK Cells Induce Neutrophil Apoptosis via an NKp46- and Fas-Dependent Mechanism
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1668–1674, https://doi.org/10.4049/jimmunol.1102002
Natural IgM Anti-Leukocyte Autoantibodies Attenuate Excess Inflammation Mediated by Innate and Adaptive Immune Mechanisms Involving Th-17
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1675–1685, https://doi.org/10.4049/jimmunol.1101762
B Lymphocytes Treated In Vitro with Antigen Coupled to Cholera Toxin B Subunit Induce Antigen-Specific Foxp3+ Regulatory T Cells and Protect against Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1686–1697, https://doi.org/10.4049/jimmunol.1101771
Murine Regulatory T Cells Contain Hyperproliferative and Death-Prone Subsets with Differential ICOS Expression
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1698–1707, https://doi.org/10.4049/jimmunol.1102448
Human γδ T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1708–1716, https://doi.org/10.4049/jimmunol.1102654
Single-Cell Network Profiling of Peripheral Blood Mononuclear Cells from Healthy Donors Reveals Age- and Race-Associated Differences in Immune Signaling Pathway Activation
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1717–1725, https://doi.org/10.4049/jimmunol.1102514
Diverse Functions of Distal Regulatory Elements at the IFNG Locus
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1726–1733, https://doi.org/10.4049/jimmunol.1102879
Allergen-Specific CTL Require Perforin Expression To Suppress Allergic Airway Inflammation
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1734–1741, https://doi.org/10.4049/jimmunol.1102699
The Living Eye “Disarms” Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1742–1750, https://doi.org/10.4049/jimmunol.1102415
CD64 Expression Distinguishes Monocyte-Derived and Conventional Dendritic Cells and Reveals Their Distinct Role during Intramuscular Immunization
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1751–1760, https://doi.org/10.4049/jimmunol.1102744
IL-1 Receptor Signaling Is Required at Multiple Stages of Sensitization and Elicitation of the Contact Hypersensitivity Response
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1761–1771, https://doi.org/10.4049/jimmunol.1100928
Tetracyclines Convert the Osteoclastic-Differentiation Pathway of Progenitor Cells To Produce Dendritic Cell-like Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1772–1781, https://doi.org/10.4049/jimmunol.1101174
Vaccines Targeting Tumor Blood Vessel Antigens Promote CD8+ T Cell-Dependent Tumor Eradication or Dormancy in HLA-A2 Transgenic Mice
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1782–1788, https://doi.org/10.4049/jimmunol.1101644
Synergism between Curdlan and GM-CSF Confers a Strong Inflammatory Signature to Dendritic Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1789–1798, https://doi.org/10.4049/jimmunol.1101755
Airway Activation of Formyl Peptide Receptors Inhibits Th1 and Th17 Cell Responses via Inhibition of Mediator Release from Immune and Inflammatory Cells and Maturation of Dendritic Cells
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1799–1808, https://doi.org/10.4049/jimmunol.1102481
Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1809–1818, https://doi.org/10.4049/jimmunol.1101746
Molecular and Structural Immunology
Structural Elucidation of the Mechanistic Basis of Degeneracy in the Primary Humoral Response
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1819–1827, https://doi.org/10.4049/jimmunol.1102701
Cullin 4B Is Recruited to Tristetraprolin-Containing Messenger Ribonucleoproteins and Regulates TNF-α mRNA Polysome Loading
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1828–1839, https://doi.org/10.4049/jimmunol.1102837
Conventional Dendritic Cells Require IRAP-Rab14 Endosomes for Efficient Cross-Presentation
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1840–1846, https://doi.org/10.4049/jimmunol.1101504
2-Deoxy d-Glucose Prevents Cell Surface Expression of NKG2D Ligands through Inhibition of N-Linked Glycosylation
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1847–1855, https://doi.org/10.4049/jimmunol.1004085
Characterization of the Promoter and the Transcriptional Regulation of the Lipoxin A4 Receptor (FPR2/ALX) Gene in Human Monocytes and Macrophages
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1856–1867, https://doi.org/10.4049/jimmunol.1101788
Immunogenetics
A Proposed Algorithm Predictive for Cytotoxic T Cell Alloreactivity
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1868–1873, https://doi.org/10.4049/jimmunol.1102086
The IL-7Rα Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1874–1883, https://doi.org/10.4049/jimmunol.1102559
Host Defense
ExoS and ExoT ADP Ribosyltransferase Activities Mediate Pseudomonas aeruginosa Keratitis by Promoting Neutrophil Apoptosis and Bacterial Survival
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1884–1895, https://doi.org/10.4049/jimmunol.1102148
Plac8-Dependent and Inducible NO Synthase-Dependent Mechanisms Clear Chlamydia muridarum Infections from the Genital Tract
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1896–1904, https://doi.org/10.4049/jimmunol.1102764
IL-12Rβ2 Is Essential for the Development of Experimental Cerebral Malaria
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1905–1914, https://doi.org/10.4049/jimmunol.1101978
STAT1-Independent Control of a Neurotropic Measles Virus Challenge in Primary Neurons and Infected Mice
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1915–1923, https://doi.org/10.4049/jimmunol.1101356
IL-21 Promotes the Pathologic Immune Response to Pneumovirus Infection
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1924–1932, https://doi.org/10.4049/jimmunol.1100767
Defective CD8 T Cell Responses in Aged Mice Are Due to Quantitative and Qualitative Changes in Virus-Specific Precursors
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1933–1941, https://doi.org/10.4049/jimmunol.1101098
Trypanosoma cruzi Immune Evasion Mediated by Host Cell-Derived Microvesicles
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1942–1952, https://doi.org/10.4049/jimmunol.1102053
Activation of the NLRP3 Inflammasome by Group B Streptococci
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1953–1960, https://doi.org/10.4049/jimmunol.1102543
Alcohol Impairs the Myeloid Proliferative Response to Bacteremia in Mice by Inhibiting the Stem Cell Antigen-1/ERK Pathway
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1961–1969, https://doi.org/10.4049/jimmunol.1102395
Inflammation
Matrix Metalloproteinase-Dependent Microsomal Prostaglandin E Synthase-1 Expression in Macrophages: Role of TNF-α and the EP4 Prostanoid Receptor
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1970–1980, https://doi.org/10.4049/jimmunol.1102383
Anti–IL-20 Monoclonal Antibody Suppresses Breast Cancer Progression and Bone Osteolysis in Murine Models
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1981–1991, https://doi.org/10.4049/jimmunol.1102843
Caspase-4 Is Required for Activation of Inflammasomes
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 1992–2000, https://doi.org/10.4049/jimmunol.1101620
CD69 Regulates Type I IFN-Induced Tolerogenic Signals to Mucosal CD4 T Cells That Attenuate Their Colitogenic Potential
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 2001–2013, https://doi.org/10.4049/jimmunol.1100765
Membrane-Tethered MUC1 Mucin Is Phosphorylated by Epidermal Growth Factor Receptor in Airway Epithelial Cells and Associates with TLR5 To Inhibit Recruitment of MyD88
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 2014–2022, https://doi.org/10.4049/jimmunol.1102405
Clinical Immunology
Human MSH6 Deficiency Is Associated with Impaired Antibody Maturation
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 2023–2029, https://doi.org/10.4049/jimmunol.1102984
A Novel C3 Mutation Causing Increased Formation of the C3 Convertase in Familial Atypical Hemolytic Uremic Syndrome
The Journal of Immunology, Volume 188, Issue 4, February 2012, Pages 2030–2037, https://doi.org/10.4049/jimmunol.1100319
Corrections
Correction: In Vivo Analysis of Ifn-γ1 and Ifn-γ2 Signaling in Zebrafish
The Journal of Immunology, Volume 188, Issue 4, February 2012, Page 2038, https://doi.org/10.4049/jimmunol.1190091
