Volume 180, Issue 6
March 2008
Cover image
Cover image
On the cover: Zymosan-induced arthritis in CD44+/+ mouse. Sagittal section of the whole knee joint from a CD44+/+ mouse at 7 days after induction of arthritis with zymosan: H&E, ×100. The moderate acute inflammatory response was partly found in the meniscus of the knee joint. Kawana, H., H. Karaki, M. Higashi, M. Miyazaki, F. Hilberg, M. Kitagawa, and K. Harigaya. 2008. CD44 suppresses TLR-mediated inflammation. J. Immunol. 180: 4235–4245.
ISSN 0022-1767
EISSN 1550-6606
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Volume 180, Issue 6, March 2008
In this Issue
In This Issue
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3623–3624, https://doi.org/10.4049/jimmunol.180.6.3623
Letters to the Editor
Comment on “MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells”
The Journal of Immunology, Volume 180, Issue 6, March 2008, Page 3625, https://doi.org/10.4049/jimmunol.180.6.3625
Response to Comment on “MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells”
The Journal of Immunology, Volume 180, Issue 6, March 2008, Page 3626, https://doi.org/10.4049/jimmunol.180.6.3626
Brief Reviews
NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3627–3635, https://doi.org/10.4049/jimmunol.180.6.3627
Cutting Edge
Cutting Edge: Programmed Death-1 Expression Is Increased on Immunocytes in Chronic Hepatitis C Virus and Predicts Failure of Response to Antiviral Therapy: Race-Dependent Differences
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3637–3641, https://doi.org/10.4049/jimmunol.180.6.3637
Cutting Edge: A Naturally Occurring Mutation in CD1e Impairs Lipid Antigen Presentation
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3642–3646, https://doi.org/10.4049/jimmunol.180.6.3642
Cutting Edge: Langerin/CD207 Receptor on Dendritic Cells Mediates Efficient Antigen Presentation on MHC I and II Products In Vivo
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3647–3650, https://doi.org/10.4049/jimmunol.180.6.3647
Cutting Edge: Human CD4−CD8− Thymocytes Express FOXP3 in the Absence of a TCR
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3651–3654, https://doi.org/10.4049/jimmunol.180.6.3651
Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3655–3659, https://doi.org/10.4049/jimmunol.180.6.3655
Cellular Immunology and Immune Regulation
Estrogen Receptor α, but Not β, Is Required for Optimal Dendritic Cell Differentiation and CD40-Induced Cytokine Production
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3661–3669, https://doi.org/10.4049/jimmunol.180.6.3661
Morphine Withdrawal Inhibits IL-12 Induction in a Macrophage Cell Line through a Mechanism That Involves cAMP
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3670–3679, https://doi.org/10.4049/jimmunol.180.6.3670
Monocyte Cell Surface Glycosaminoglycans Positively Modulate IL-4-Induced Differentiation toward Dendritic Cells
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3680–3688, https://doi.org/10.4049/jimmunol.180.6.3680
Non-T Cell Activation Linker Promotes Mast Cell Survival by Dampening the Recruitment of SHIP1 by Linker for Activation of T Cells
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3689–3698, https://doi.org/10.4049/jimmunol.180.6.3689
E2F4 Modulates Differentiation and Gene Expression in Hematopoietic Progenitor Cells during Commitment to the Lymphoid Lineage
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3699–3707, https://doi.org/10.4049/jimmunol.180.6.3699
Allelic and Isotypic Light Chain Inclusion in Peripheral B Cells from Anti-DNA Antibody Transgenic C57BL/6 and BALB/c Mice
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3708–3718, https://doi.org/10.4049/jimmunol.180.6.3708
The Use of Filamentous Bacteriophage fd to Deliver MAGE-A10 or MAGE-A3 HLA-A2-Restricted Peptides and to Induce Strong Antitumor CTL Responses
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3719–3728, https://doi.org/10.4049/jimmunol.180.6.3719
Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3729–3738, https://doi.org/10.4049/jimmunol.180.6.3729
CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3739–3745, https://doi.org/10.4049/jimmunol.180.6.3739
Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3746–3756, https://doi.org/10.4049/jimmunol.180.6.3746
IL-15 Does Not Affect IEL Development in the Thymus but Regulates Homeostasis of Putative Precursors and Mature CD8αα+ IELs in the Intestine
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3757–3765, https://doi.org/10.4049/jimmunol.180.6.3757
Modulation of the Tumor Cell Phenotype by IFN-γ Results in Resistance of Uveal Melanoma Cells to Granule-Mediated Lysis by Cytotoxic Lymphocytes
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3766–3774, https://doi.org/10.4049/jimmunol.180.6.3766
Telomerase Is Involved in IL-7-Mediated Differential Survival of Naive and Memory CD4+ T Cells
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3775–3781, https://doi.org/10.4049/jimmunol.180.6.3775
Human Lymphocyte Activation Gene-3 Molecules Expressed by Activated T Cells Deliver Costimulation Signal for Dendritic Cell Activation
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3782–3788, https://doi.org/10.4049/jimmunol.180.6.3782
IFN-β Provides Immuno-Protection in the Retina by Inhibiting ICAM-1 and CXCL9 in Retinal Pigment Epithelial Cells
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3789–3796, https://doi.org/10.4049/jimmunol.180.6.3789
Attenuating Regulatory T Cell Induction by TLR Agonists through Inhibition of p38 MAPK Signaling in Dendritic Cells Enhances Their Efficacy as Vaccine Adjuvants and Cancer Immunotherapeutics
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3797–3806, https://doi.org/10.4049/jimmunol.180.6.3797
A Lupus-Suppressor BALB/c Locus Restricts IgG2 Autoantibodies without Altering Intrinsic B Cell-Tolerance Mechanisms
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3807–3814, https://doi.org/10.4049/jimmunol.180.6.3807
A Novel B7-2 (CD86) Splice Variant with a Putative Negative Regulatory Role
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3815–3823, https://doi.org/10.4049/jimmunol.180.6.3815
A Specific Anti-Aire Antibody Reveals Aire Expression Is Restricted to Medullary Thymic Epithelial Cells and Not Expressed in Periphery
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3824–3832, https://doi.org/10.4049/jimmunol.180.6.3824
Differential Sensitivity to Itk Kinase Signals for T Helper 2 Cytokine Production and Chemokine-Mediated Migration
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3833–3838, https://doi.org/10.4049/jimmunol.180.6.3833
Ig Knock-In Mice Producing Anti-Carbohydrate Antibodies: Breakthrough of B Cells Producing Low Affinity Anti-Self Antibodies
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3839–3848, https://doi.org/10.4049/jimmunol.180.6.3839
First Signature of Islet β-Cell-Derived Naturally Processed Peptides Selected by Diabetogenic Class II MHC Molecules
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3849–3856, https://doi.org/10.4049/jimmunol.180.6.3849
Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3857–3865, https://doi.org/10.4049/jimmunol.180.6.3857
Neuroprotective Immunity: T Cell-Derived Glutamate Endows Astrocytes with a Neuroprotective Phenotype
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3866–3873, https://doi.org/10.4049/jimmunol.180.6.3866
Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3874–3881, https://doi.org/10.4049/jimmunol.180.6.3874
TLR Agonists Promote Marginal Zone B Cell Activation and Facilitate T-Dependent IgM Responses
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3882–3888, https://doi.org/10.4049/jimmunol.180.6.3882
Lipopolysaccharide-Activated IL-10-Secreting Dendritic Cells Suppress Experimental Autoimmune Uveoretinitis by MHCII-Dependent Activation of CD62L-Expressing Regulatory T Cells
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3889–3899, https://doi.org/10.4049/jimmunol.180.6.3889
A Role for CD8 in the Developmental Tuning of Antigen Recognition and CD3 Conformational Change
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3900–3909, https://doi.org/10.4049/jimmunol.180.6.3900
Homeostatic Proliferation of Lymphocytes Results in Augmented Memory-Like Function and Accelerated Allograft Rejection
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3910–3918, https://doi.org/10.4049/jimmunol.180.6.3910
Postnatal Life Events Affect the Severity of Asthmatic Airway Inflammation in the Adult Rat
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3919–3925, https://doi.org/10.4049/jimmunol.180.6.3919
Molecular and Structural Immunology
Structural and Biological Basis of CTL Escape in Coronavirus-Infected Mice
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3926–3937, https://doi.org/10.4049/jimmunol.180.6.3926
Filamin A Stabilizes FcγRI Surface Expression and Prevents Its Lysosomal Routing
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3938–3945, https://doi.org/10.4049/jimmunol.180.6.3938
Structural Insight into the Function of Myelin Basic Protein as a Ligand for Integrin αMβ2
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3946–3956, https://doi.org/10.4049/jimmunol.180.6.3946
Autoantibody Profiling in Multiple Sclerosis Reveals Novel Antigenic Candidates
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3957–3963, https://doi.org/10.4049/jimmunol.180.6.3957
A Novel Mechanism of Complement Inhibition Unmasked by a Tick Salivary Protein That Binds to Properdin
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3964–3968, https://doi.org/10.4049/jimmunol.180.6.3964
Immunogenetics
Synergistic Polymorphism at Two Positions Distal to the Ligand-Binding Site Makes KIR2DL2 a Stronger Receptor for HLA-C Than KIR2DL3
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3969–3979, https://doi.org/10.4049/jimmunol.180.6.3969
Host Defense
Functional Maturation of the Human Antibody Response to Rotavirus
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3980–3989, https://doi.org/10.4049/jimmunol.180.6.3980
Sporozoite-Mediated Hepatocyte Wounding Limits Plasmodium Parasite Development via MyD88-Mediated NF-κB Activation and Inducible NO Synthase Expression
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 3990–3999, https://doi.org/10.4049/jimmunol.180.6.3990
Suppression of an Already Established Tumor Growing through Activated Mucosal CTLs Induced by Oral Administration of Tumor Antigen with Cholera Toxin
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4000–4010, https://doi.org/10.4049/jimmunol.180.6.4000
Identification of an N-Linked Glycosylation in the C4 Region of HIV-1 Envelope gp120 That Is Critical for Recognition of Neighboring CD4 T Cell Epitopes
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4011–4021, https://doi.org/10.4049/jimmunol.180.6.4011
Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4022–4031, https://doi.org/10.4049/jimmunol.180.6.4022
Potent Antimycobacterial Activity of Mouse Secretory Leukocyte Protease Inhibitor
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4032–4039, https://doi.org/10.4049/jimmunol.180.6.4032
SOCS-1 Protects against Chlamydia pneumoniae-Induced Lethal Inflammation but Hampers Effective Bacterial Clearance
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4040–4049, https://doi.org/10.4049/jimmunol.180.6.4040
Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4050–4057, https://doi.org/10.4049/jimmunol.180.6.4050
Functional CD8+ T Cell Responses in Lethal Ebola Virus Infection
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4058–4066, https://doi.org/10.4049/jimmunol.180.6.4058
Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4067–4074, https://doi.org/10.4049/jimmunol.180.6.4067
Functional Adaptation of Nef to the Immune Milieu of HIV-1 Infection In Vivo
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4075–4081, https://doi.org/10.4049/jimmunol.180.6.4075
Activation of Human NK Cells by the Bacterial Pathogen-Associated Molecular Pattern Muramyl Dipeptide
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4082–4089, https://doi.org/10.4049/jimmunol.180.6.4082
IL-10 and TGF-β Control the Establishment of Persistent and Transmissible Infections Produced by Leishmania tropica in C57BL/6 Mice
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4090–4097, https://doi.org/10.4049/jimmunol.180.6.4090
Characterization of Pulmonary T Cell Response to Helper-Dependent Adenoviral Vectors following Intranasal Delivery
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4098–4108, https://doi.org/10.4049/jimmunol.180.6.4098
Deviation from a Strong Th1-Dominated to a Modest Th17-Dominated CD4 T Cell Response in the Absence of IL-12p40 and Type I IFNs Sustains Protective CD8 T Cells
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4109–4115, https://doi.org/10.4049/jimmunol.180.6.4109
IFN-β Increases Listeriolysin O-Induced Membrane Permeabilization and Death of Macrophages
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4116–4123, https://doi.org/10.4049/jimmunol.180.6.4116
Mannose-Binding Lectin (MBL) Facilitates Opsonophagocytosis of Yeasts but Not of Bacteria despite MBL Binding
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4124–4132, https://doi.org/10.4049/jimmunol.180.6.4124
Role of Polymorphonuclear Neutrophils on Infectious Complications Stemming from Enterococcus faecalis Oral Infection in Thermally Injured Mice
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4133–4138, https://doi.org/10.4049/jimmunol.180.6.4133
Anthrax Lethal Toxin Increases Superoxide Production in Murine Neutrophils via Differential Effects on MAPK Signaling Pathways
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4139–4147, https://doi.org/10.4049/jimmunol.180.6.4139
Endogenous IFN-γ Production Is Induced and Required for Protective Immunity against Pulmonary Chlamydial Infection in Neonatal Mice
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4148–4155, https://doi.org/10.4049/jimmunol.180.6.4148
Spleen Size Predicts Resistance of Rainbow Trout to Flavobacterium psychrophilum Challenge
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4156–4165, https://doi.org/10.4049/jimmunol.180.6.4156
Inflammation
ERK5/BMK1 Is Indispensable for Optimal Colony-Stimulating Factor 1 (CSF-1)-Induced Proliferation in Macrophages in a Src-Dependent Fashion
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4166–4172, https://doi.org/10.4049/jimmunol.180.6.4166
Adenosine Promotes IL-6 Release in Airway Epithelia
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4173–4181, https://doi.org/10.4049/jimmunol.180.6.4173
Cross-Talk between ICAM-1 and GM-CSF Receptor Signaling Modulates Eosinophil Survival and Activation
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4182–4190, https://doi.org/10.4049/jimmunol.180.6.4182
Dual Modulation of Airway Smooth Muscle Contraction by Th2 Cytokines via Matrix Metalloproteinase-1 Production
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4191–4199, https://doi.org/10.4049/jimmunol.180.6.4191
STAT-1 Signaling in Human Lung Fibroblasts Is Induced by Vanadium Pentoxide through an IFN-β Autocrine Loop
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4200–4207, https://doi.org/10.4049/jimmunol.180.6.4200
Induced Loss of Syk in Human Basophils by Non-IgE-Dependent Stimuli
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4208–4217, https://doi.org/10.4049/jimmunol.180.6.4208
Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4218–4226, https://doi.org/10.4049/jimmunol.180.6.4218
Neuritogenic Effects of T Cell-Derived IL-3 on Mouse Splenic Sympathetic Neurons In Vivo
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4227–4234, https://doi.org/10.4049/jimmunol.180.6.4227
CD44 Suppresses TLR-Mediated Inflammation
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4235–4245, https://doi.org/10.4049/jimmunol.180.6.4235
Control of IFN-αA by CD73: Implications for Mucosal Inflammation
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4246–4255, https://doi.org/10.4049/jimmunol.180.6.4246
A Phosphosite Screen Identifies Autocrine TGF-β-Driven Activation of Protein Kinase R as a Survival-Limiting Factor for Eosinophils
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4256–4264, https://doi.org/10.4049/jimmunol.180.6.4256
A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4265–4272, https://doi.org/10.4049/jimmunol.180.6.4265
A Critical Role for ABCG1 in Macrophage Inflammation and Lung Homeostasis
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4273–4282, https://doi.org/10.4049/jimmunol.180.6.4273
Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4283–4291, https://doi.org/10.4049/jimmunol.180.6.4283
Delivery of Biologically Active Anti-Inflammatory Cytokines IL-10 and IL-1ra In Vivo by the Shigella Type III Secretion Apparatus
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4292–4298, https://doi.org/10.4049/jimmunol.180.6.4292
Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4299–4307, https://doi.org/10.4049/jimmunol.180.6.4299
Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4308–4315, https://doi.org/10.4049/jimmunol.180.6.4308
C-Reactive Protein-Bound Enzymatically Modified Low-Density Lipoprotein Does Not Transform Macrophages into Foam Cells
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4316–4322, https://doi.org/10.4049/jimmunol.180.6.4316
The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4323–4329, https://doi.org/10.4049/jimmunol.180.6.4323
Clinical Immunology
Analysis of HLA-G in Maternal Plasma, Follicular Fluid, and Preimplantation Embryos Reveal an Asymmetric Pattern of Expression
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4330–4337, https://doi.org/10.4049/jimmunol.180.6.4330
Tumor Cell Killing Mechanisms of Epidermal Growth Factor Receptor (EGFR) Antibodies Are Not Affected by Lung Cancer-Associated EGFR Kinase Mutations
The Journal of Immunology, Volume 180, Issue 6, March 2008, Pages 4338–4345, https://doi.org/10.4049/jimmunol.180.6.4338
