Volume 178, Issue 7
April 2007
Cover image
Cover image
On the cover: Islets infected with indoleamine 2,3-dioxygenase (IDO) adenovirus are transplanted under the kidney capsule. Then the kidney is fixed, paraffin-embedded, sectioned, and stained for IDO expression. The image shows IDO expression by islet grafts. Liu, Z., H. Dai, N. Wan, T. Wang, S. Bertera, M. Trucco, and Z. Dai. 2007. Suppression of memory CD8 T cell generation and function by tryptophan catabolism. J. Immunol. 178: 4260–4266.
ISSN 0022-1767
EISSN 1550-6606
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Volume 178, Issue 7, April 2007
In This Issue
In This Issue
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4003–4004, https://doi.org/10.4049/jimmunol.178.7.4003
Pillars of Immunology
Allophenic Mice: A Pillar Awaiting Its Superstructure
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4005–4006, https://doi.org/10.4049/jimmunol.178.7.4005
Pillars Article: “Intrinsic” Immunological Tolerance in Allophenic Mice. Science 1967. 158: 1484–1487
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4007–4010, https://doi.org/10.1093/jimmunol.178.7.4007
Brief Reviews
NK Cells and Cancer
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4011–4016, https://doi.org/10.4049/jimmunol.178.7.4011
Cutting Edge
Cutting Edge: Immature Human Dendritic Cells Express Latency-Associated Peptide and Inhibit T Cell Activation in a TGF-β-Dependent Manner
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4017–4021, https://doi.org/10.4049/jimmunol.178.7.4017
Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4022–4026, https://doi.org/10.4049/jimmunol.178.7.4022
Cutting Edge: Limiting Amounts of IL-7 Do Not Control Contraction of CD4+ T Cell Responses
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4027–4031, https://doi.org/10.4049/jimmunol.178.7.4027
Cellular Immunology and Immune Regulation
The T Cell Costimulator TL1A Is Induced by FcγR Signaling in Human Monocytes and Dendritic Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4033–4038, https://doi.org/10.4049/jimmunol.178.7.4033
15-Deoxy-Δ12,14-Prostaglandin J2 Negatively Regulates rankl Gene Expression in Activated T Lymphocytes: Role of NF-κB and Early Growth Response Transcription Factors
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4039–4050, https://doi.org/10.4049/jimmunol.178.7.4039
Follicular Lymphoma Intratumoral CD4+CD25+GITR+ Regulatory T Cells Potently Suppress CD3/CD28-Costimulated Autologous and Allogeneic CD8+CD25− and CD4+CD25− T Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4051–4061, https://doi.org/10.4049/jimmunol.178.7.4051
Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4062–4071, https://doi.org/10.4049/jimmunol.178.7.4062
Natural and Synthetic TLR7 Ligands Inhibit CpG-A- and CpG-C-Oligodeoxynucleotide-Induced IFN-α Production
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4072–4079, https://doi.org/10.4049/jimmunol.178.7.4072
Functional Plasticity in Memory T Helper Cell Responses
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4080–4088, https://doi.org/10.4049/jimmunol.178.7.4080
Infiltration of a Mesothelioma by IFN-γ-Producing Cells and Tumor Rejection after Depletion of Regulatory T Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4089–4096, https://doi.org/10.4049/jimmunol.178.7.4089
Prostaglandin E2 Induces the Expression of IL-1α in Colon Cancer Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4097–4103, https://doi.org/10.4049/jimmunol.178.7.4097
Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4104–4111, https://doi.org/10.4049/jimmunol.178.7.4104
Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4112–4119, https://doi.org/10.4049/jimmunol.178.7.4112
The Constitutive Tyrosine Phosphorylation of CD3ζ Results from TCR-MHC Interactions That Are Independent of Thymic Selection
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4120–4128, https://doi.org/10.4049/jimmunol.178.7.4120
Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Immunoregulation: Enhancement of Regulatory T Cells through PPARγ-Dependent and -Independent Mechanisms
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4129–4135, https://doi.org/10.4049/jimmunol.178.7.4129
Incomplete Depletion and Rapid Regeneration of Foxp3+ Regulatory T Cells Following Anti-CD25 Treatment in Malaria-Infected Mice
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4136–4146, https://doi.org/10.4049/jimmunol.178.7.4136
The Blood Contains Multiple Distinct Progenitor Populations with Clonogenic B and T Lineage Potential
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4147–4152, https://doi.org/10.4049/jimmunol.178.7.4147
Gadd45α Regulates p38-Dependent Dendritic Cell Cytokine Production and Th1 Differentiation
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4153–4158, https://doi.org/10.4049/jimmunol.178.7.4153
Minor Antigen H60-Mediated Aplastic Anemia Is Ameliorated by Immunosuppression and the Infusion of Regulatory T Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4159–4168, https://doi.org/10.4049/jimmunol.178.7.4159
Delivery of Antigen to CD40 Induces Protective Immune Responses against Tumors
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4169–4176, https://doi.org/10.4049/jimmunol.178.7.4169
FcεRI Aggregation Promotes Survival of Connective Tissue-Like Mast Cells but Not Mucosal-Like Mast Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4177–4183, https://doi.org/10.4049/jimmunol.178.7.4177
Human Dendritic Cells Acquire a Semimature Phenotype and Lymph Node Homing Potential through Interaction with CD4+CD25+ Regulatory T Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4184–4193, https://doi.org/10.4049/jimmunol.178.7.4184
Cytokine-Mediated Disruption of Lymphocyte Trafficking, Hemopoiesis, and Induction of Lymphopenia, Anemia, and Thrombocytopenia in Anti-CD137-Treated Mice
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4194–4213, https://doi.org/10.4049/jimmunol.178.7.4194
Non-Cell Autonomous Expression of TNF-α-Converting Enzyme ADAM17 Is Required for Normal Lymphocyte Development
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4214–4221, https://doi.org/10.4049/jimmunol.178.7.4214
Regulation of Carcinogenesis by IL-5 and CCL11: A Potential Role for Eosinophils in Tumor Immune Surveillance
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4222–4229, https://doi.org/10.4049/jimmunol.178.7.4222
Mouse TCRαβ+CD8αα Intraepithelial Lymphocytes Express Genes That Down-Regulate Their Antigen Reactivity and Suppress Immune Responses
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4230–4239, https://doi.org/10.4049/jimmunol.178.7.4230
Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4240–4249, https://doi.org/10.4049/jimmunol.178.7.4240
Paired Ig-Like Receptors Bind to Bacteria and Shape TLR-Mediated Cytokine Production
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4250–4259, https://doi.org/10.4049/jimmunol.178.7.4250
Suppression of Memory CD8 T Cell Generation and Function by Tryptophan Catabolism
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4260–4266, https://doi.org/10.4049/jimmunol.178.7.4260
Genetic Deletion of Placenta Growth Factor in Mice Alters Uterine NK Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4267–4275, https://doi.org/10.4049/jimmunol.178.7.4267
Limited Peripheral T Cell Anergy Predisposes to Retinal Autoimmunity
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4276–4283, https://doi.org/10.4049/jimmunol.178.7.4276
TGF-β Suppresses IFN-γ-STAT1-Dependent Gene Transcription by Enhancing STAT1-PIAS1 Interactions in Epithelia but Not Monocytes/Macrophages
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4284–4295, https://doi.org/10.4049/jimmunol.178.7.4284
Activation of Enteroendocrine Cells via TLRs Induces Hormone, Chemokine, and Defensin Secretion
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4296–4303, https://doi.org/10.4049/jimmunol.178.7.4296
Distinct Cytokine-Driven Responses of Activated Blood γδ T Cells: Insights into Unconventional T Cell Pleiotropy
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4304–4314, https://doi.org/10.4049/jimmunol.178.7.4304
Enhanced NFATc1 Nuclear Occupancy Causes T Cell Activation Independent of CD28 Costimulation
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4315–4321, https://doi.org/10.4049/jimmunol.178.7.4315
Molecular and Structural Immunology
Analysis of 6912 Unselected Somatic Hypermutations in Human VDJ Rearrangements Reveals Lack of Strand Specificity and Correlation between Phase II Substitution Rates and Distance to the Nearest 3′ Activation-Induced Cytidine Deaminase Target
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4322–4334, https://doi.org/10.4049/jimmunol.178.7.4322
CCL23 Expression Is Induced by IL-4 in a STAT6-Dependent Fashion
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4335–4341, https://doi.org/10.4049/jimmunol.178.7.4335
Human TIM-1 Associates with the TCR Complex and Up-Regulates T Cell Activation Signals
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4342–4350, https://doi.org/10.4049/jimmunol.178.7.4342
Extracellular Isoforms of CD6 Generated by Alternative Splicing Regulate Targeting of CD6 to the Immunological Synapse
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4351–4361, https://doi.org/10.4049/jimmunol.178.7.4351
Peroxisome Proliferator-Activated Receptor-α Activation Inhibits Langerhans Cell Function
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4362–4372, https://doi.org/10.4049/jimmunol.178.7.4362
Bcl10 Controls TCR- and FcγR-Induced Actin Polymerization
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4373–4384, https://doi.org/10.4049/jimmunol.178.7.4373
Immunogenetics
Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4385–4394, https://doi.org/10.4049/jimmunol.178.7.4385
The Bxs6 Locus of BXSB Mice Is Sufficient for High-Level Expression of gp70 and the Production of gp70 Immune Complexes
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4395–4401, https://doi.org/10.4049/jimmunol.178.7.4395
Human KIR2DL5 Is an Inhibitory Receptor Expressed on the Surface of NK and T Lymphocyte Subsets
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4402–4410, https://doi.org/10.4049/jimmunol.178.7.4402
Host Defense
NK Dendritic Cells Are Innate Immune Responders to Listeria monocytogenes Infection
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4411–4416, https://doi.org/10.4049/jimmunol.178.7.4411
Peptide Mimics of the Group B Meningococcal Capsule Induce Bactericidal and Protective Antibodies after Immunization
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4417–4423, https://doi.org/10.4049/jimmunol.178.7.4417
The Role of Antibody Polyspecificity and Lipid Reactivity in Binding of Broadly Neutralizing Anti-HIV-1 Envelope Human Monoclonal Antibodies 2F5 and 4E10 to Glycoprotein 41 Membrane Proximal Envelope Epitopes
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4424–4435, https://doi.org/10.4049/jimmunol.178.7.4424
TLR Ligand-Dependent Activation of Naive CD4 T Cells by Plasmacytoid Dendritic Cells Is Impaired in Hepatitis C Virus Infection
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4436–4444, https://doi.org/10.4049/jimmunol.178.7.4436
Francisella tularensis Induces IL-23 Production in Human Monocytes
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4445–4454, https://doi.org/10.4049/jimmunol.178.7.4445
T Cell Recognition Patterns of Immunodominant Cytomegalovirus Antigens in Primary and Persistent Infection
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4455–4465, https://doi.org/10.4049/jimmunol.178.7.4455
Resident Vδ1+ γδ T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4466–4472, https://doi.org/10.4049/jimmunol.178.7.4466
The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1− NK Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4473–4481, https://doi.org/10.4049/jimmunol.178.7.4473
Tyk2 Signaling in Host Environment Plays an Important Role in Contraction of Antigen-Specific CD8+ T Cells following a Microbial Infection
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4482–4488, https://doi.org/10.4049/jimmunol.178.7.4482
Factor H Binding and Function in Sialylated Pathogenic Neisseriae is Influenced by Gonococcal, but Not Meningococcal, Porin
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4489–4497, https://doi.org/10.4049/jimmunol.178.7.4489
IL-12 and Type-I IFN Synergize for IFN-γ Production by CD4 T Cells, Whereas Neither Are Required for IFN-γ Production by CD8 T Cells after Listeria monocytogenes Infection
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4498–4505, https://doi.org/10.4049/jimmunol.178.7.4498
Collagen Distribution and Expression of Collagen-Binding α1β1 (VLA-1) and α2β1 (VLA-2) Integrins on CD4 and CD8 T Cells during Influenza Infection
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4506–4516, https://doi.org/10.4049/jimmunol.178.7.4506
Evidence for Evolving Toll-IL-1 Receptor-Containing Adaptor Molecule Function in Vertebrates
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4517–4527, https://doi.org/10.4049/jimmunol.178.7.4517
MyD88-Dependent Signals Are Essential for the Host Immune Response in Experimental Brain Abscess
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4528–4537, https://doi.org/10.4049/jimmunol.178.7.4528
Active Suppression of the Pulmonary Immune Response by Francisella tularensis Schu4
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4538–4547, https://doi.org/10.4049/jimmunol.178.7.4538
Recognition of Double-Stranded RNA by TLR3 Induces Severe Small Intestinal Injury in Mice
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4548–4556, https://doi.org/10.4049/jimmunol.178.7.4548
Infection with a Helminth Parasite Prevents Experimental Colitis via a Macrophage-Mediated Mechanism
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4557–4566, https://doi.org/10.4049/jimmunol.178.7.4557
Allele- and Locus-Specific Recognition of Class I MHC Molecules by the Immunomodulatory E3-19K Protein from Adenovirus
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4567–4575, https://doi.org/10.4049/jimmunol.178.7.4567
IFN Mimetic as a Therapeutic for Lethal Vaccinia Virus Infection: Possible Effects on Innate and Adaptive Immune Responses
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4576–4583, https://doi.org/10.4049/jimmunol.178.7.4576
Inflammation
Histamine Release from the Basophils of Control and Asthmatic Subjects and a Comparison of Gene Expression between “Releaser” and “Nonreleaser” Basophils
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4584–4594, https://doi.org/10.4049/jimmunol.178.7.4584
Annexin-1 and Peptide Derivatives Are Released by Apoptotic Cells and Stimulate Phagocytosis of Apoptotic Neutrophils by Macrophages
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4595–4605, https://doi.org/10.4049/jimmunol.178.7.4595
Loss of SLP-76 Expression within Myeloid Cells Confers Resistance to Neutrophil-Mediated Tissue Damage while Maintaining Effective Bacterial Killing
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4606–4614, https://doi.org/10.4049/jimmunol.178.7.4606
Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4615–4622, https://doi.org/10.4049/jimmunol.178.7.4615
The Chemokine Binding Protein M3 Prevents Diabetes Induced by Multiple Low Doses of Streptozotocin
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4623–4631, https://doi.org/10.4049/jimmunol.178.7.4623
TGF-β1-Mediated Control of Central Nervous System Inflammation and Autoimmunity through the Inhibitory Receptor CD26
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4632–4640, https://doi.org/10.4049/jimmunol.178.7.4632
IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4641–4649, https://doi.org/10.4049/jimmunol.178.7.4641
Clinical Immunology
T Cell Activation by Antibody-Like Immunoreceptors: The Position of the Binding Epitope within the Target Molecule Determines the Efficiency of Activation of Redirected T Cells
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4650–4657, https://doi.org/10.4049/jimmunol.178.7.4650
Grass Pollen Immunotherapy Induces an Allergen-Specific IgA2 Antibody Response Associated with Mucosal TGF-β Expression
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4658–4666, https://doi.org/10.4049/jimmunol.178.7.4658
Augmentation of NZB Autoimmune Phenotypes by the Sle1c Murine Lupus Susceptibility Interval
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4667–4675, https://doi.org/10.4049/jimmunol.178.7.4667
Intratumoral Injection of α-gal Glycolipids Induces Xenograft-Like Destruction and Conversion of Lesions into Endogenous Vaccines
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4676–4687, https://doi.org/10.4049/jimmunol.178.7.4676
Prothymosin α Lacking the Nuclear Localization Signal as an Effective Gene Therapeutic Strategy in Collagen-Induced Arthritis
The Journal of Immunology, Volume 178, Issue 7, April 2007, Pages 4688–4694, https://doi.org/10.4049/jimmunol.178.7.4688
