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HyeMee Joo, Katherine Upchurch, Wei Zhang, Ling Ni, Dapeng Li, Yaming Xue, Xiao-Hua Li, Toshiyuki Hori, Sandra Zurawski, Yong-Jun Liu, Gerard Zurawski, SangKon Oh, Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and Myeloid Dendritic Cells in Th2 Polarization, The Journal of Immunology, Volume 195, Issue 4, August 2015, Pages 1723–1731, https://doi.org/10.4049/jimmunol.1402276
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Abstract
Dendritic cells (DCs) can induce and control host immune responses. DC subset-dependent functional specialties and their ability to display functional plasticity, which is mainly driven by signals via pattern recognition receptors, identify DCs as immune orchestrators. A pattern recognition receptor, Dectin-1, is expressed on myeloid DCs and known to play important roles in Th17 induction and activation during fungal and certain bacterial infections. In this study, we first demonstrate that human plasmacytoid DCs express Dectin-1 in both mRNA and protein levels. More interestingly, Dectin-1–activated plasmacytoid DCs promote Th2-type T cell responses, whereas Dectin-1–activated myeloid DCs decrease Th2-type T cell responses. Such contrasting outcomes of Th2-type T cell responses by the two DC subsets are mainly due to their distinct abilities to control surface OX40L expression in response to β-glucan. This study provides new insights for the regulation of host immune responses by Dectin-1 expressed on DCs.