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Qingguo Ruan, Peng Wang, Ting Wang, Ji Qi, Monica Wei, Shaowen Wang, Tingting Fan, Derek Johnson, Xiaochun Wan, Weiyun Shi, Honghong Sun, Youhai Chen, MicroRNA-21 regulates T cell apoptosis by directly targeting the tumor suppressor gene Tipe2 (IRM10P.755), The Journal of Immunology, Volume 192, Issue Supplement_1, May 2014, Page 129.22, https://doi.org/10.4049/jimmunol.192.Supp.129.22
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Abstract
MicroRNAs (MiRs) are short non-coding RNAs that can regulate gene expression. It has been reported that miR-21 suppresses apoptosis in activated T cells, but the molecular mechanism remains undefined. Tumor suppressor Tipe2 is a newly identified anti-inflammatory protein of the TNFAIP8 family that is essential for maintaining immune homeostasis. We report here that miR-21 is a direct target of NF-κB and could regulate Tipe2 expression in a Tipe2 coding region-dependent manner. In activated T cells and macrophages, Tipe2 expression was markedly down-regulated while miR-21 expression up-regulated. Importantly, Tipe2-deficient T cells were significantly less sensitive to apoptosis. Conversely, over-expression of Tipe2 in EL-4 T cells increased their susceptibility to activation-induced apoptosis. Therefore, Tipe2 provides a molecular bridge between miR-21 and cell apoptosis; MiR-21 suppresses apoptosis in activated T cells at least in part through directly targeting tumor suppressor gene Tipe2.
