-
Views
-
Cite
Cite
Dawn M Jelley-Gibbs, Kai McKinstry, Tara Strutt, John Dibble, Susan Swain, CD4 T cell memory of prior influenza infections regulate new CD4 and CD8 T cell responses (43.3), The Journal of Immunology, Volume 178, Issue 1_Supplement, April 2007, Page S36, https://doi.org/10.4049/jimmunol.178.Supp.43.3
Close - Share Icon Share
Abstract
Acute infections are often characterized by short-lived antigen presentation, but influenza infection results in long-lived antigen depots capable of stimulating CD4 and CD8 T cells long after live virus clearance. FACS purification of antigen presenting cells from mice at various times after flu infection, followed by co-culture with naive flu-specific T cells, has demonstrated that dendritic cells are the perpetrators of long-lived flu antigen presentation. However, there may be a reservoir of intact virus that persists at low levels in other cell populations. Regardless of the mechanism of antigen retention, access to long-lived flu antigen presentation is important for the generation of flu-specific memory T cells. Manipulations of our model system that result in enhanced circulation of effector T cells in the periphery of flu infected mice lead to impressive increases in memory T cell generation. Specifically, introduction of flu-experienced memory CD4 T cells during new CD4 and CD8 T cell priming, as well as induction of physical redistribution of newly primed effectors, results in greater effector circulation in peripheral sites and increased numbers of memory T cells. We propose that recirculation of effector T cells during flu infection allows for greater access to long-lived antigen depots, and consequently results in higher numbers of memory T cells.
Funding provided by NIH grant AI46530.
