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Junqi Yang, Marat Khodoun, Tatyana Orekov, Katja Mohrs, Crystal Potter, Markus Mohrs, Fred D Finkelman, Shift from IL-3- to IgE-induced IL-4 production as basophils become a predominant source of IL-4 (37.15), The Journal of Immunology, Volume 178, Issue 1_Supplement, April 2007, Page S21, https://doi.org/10.4049/jimmunol.178.Supp.37.15
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Abstract
We compared CD4+ T cell and basophil contributions to in vivo IL-4 production and evaluated stimuli that induce basophil IL-4 production during immune responses to a protein Ag, goat anti-mouse IgD antiserum (GaMD), and a nematode parasite. IL-4 production by basophils preceded CD4+ T cells, but CD4+ T cells produced most IL-4 secreted during the primary response to GAMD and the secondary response to Ag challenge 4–5 d after priming. In contrast, basophils produced most of the IL-4 secreted in mice challenged 12–14 d after priming. Basophil IL-4 secretion was IL-3-dependent but influenced by IgE during the primary response and IL-3- and CD4+ T cell-dependent/IgE-independent during the d 4–5 secondary response, but was IgE-dependent and IL-3/CD4+ T cell-independent during the d 12–14 secondary response. Basophil IL-4 secretion during a primary infection with Trichinella spiralis was localized to the liver and was partially IL-3- and IgE-independent. Thus, IL-3-dependent basophil IL-4 production precedes and supplements the primary T cell IL-4 response to a protein Ag; basophil IL-4 production can exceed T cell IL-4 production in animals challenged with Ag after basophils are primed by Ag-specific IgE; and helminthic parasites can stimulate basophil IL-4 secretion through a distinct mechanism.
