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Meenakshi Arora, Anuradha Ray, Prabir Ray, Exposure to LPS induces the generation of immunosuppressive myeloid cells (95.7), The Journal of Immunology, Volume 178, Issue 1_Supplement, April 2007, Page S178, https://doi.org/10.4049/jimmunol.178.Supp.95.7
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Abstract
The biologic effects of lipopolysaccharide (LPS) may have different consequences on the expression of asthma dependent upon whether the exposure to LPS occurs during the establishment of the atopic status, or whether the exposure to LPS occurs after the asthma phenotype is established. It has been shown that exposure to LPS during early childhood is associated with a lower incidence of asthma later in the life. Dendritic cells (DCs) are the primary antigen presenting cells of the immune system and play critical role in the induction of peripheral tolerance and regulation of T-cell responses. The diverse functions of DCs in immunity and tolerance depend on their lineage and maturation stage. We have observed that exposure of LPS can generate a population of immature myeloid cells that have potent immunosuppressive activity on T cells. These CD11c− cells are largely MHC IIlow/MHC II- and have poor antigen presenting capacity. These cells poorly stimulate proliferation of naïve allogenic T cells and are unable to stimulate T cell differentiation along the Th1 or Th2 lineage. However, these cells are capable of suppressing the proliferation and differentiation of activated CD4+ T cells both in vitro and in vivo. Our data shows that LPS reduces DC driven T cell development through the induction of cells with suppressive activity, which could be a potential strategy to suppress harmful T-cell responses in patients with allergic diseases.
(RO1 HL60207 to P.R. and RO1 HL77430 to A.R.)
