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So-Young Eun, Brian Patrick O’Connor, Athena W Wong, Zhengmao Ye, Jenny P-Y Ting, Plexin-A1 on dendritic cells and its interaction with a T cell surface molecule (B11), The Journal of Immunology, Volume 178, Issue 1_Supplement, April 2007, Pages LB2–LB3, https://doi.org/10.4049/jimmunol.178.Supp.B11
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Abstract
Plexin-A1 was first discovered on neurons and found to cause growth cone collapse in response to semaphorin3A, a repelling cue. Interestingly, we and others have recently observed that plexin-A1 is also an important factor for the interaction between antigen-presenting cells and T cells (Wong, A. W., et al. 2003, Nat. Immunol.; Takegahara, N., et al. 2006, Nat. Cell Biol.). Plexin-A1 on dendritic cells is shown to play a significant role in fully activating antigen-specific T cells in their co-culture. Effect of plexin-A1 on T cell activation is shown to be signaled through the Rho GTPase to accumulate actin filaments toward immune synapse (Eun, S.-Y., et al., 2006, J. Immunol.). Our group and others have identified a ligand for plexin-A1 on T cells as the semaphorin6D molecule, which is upregulated on activated T cells. In the co-culture of DCs and T cells, we observed that T cell proliferation became significantly reduced by intervention of soluble sema6D fusion protein conjugated with human IgG. Signaling events in T cell activation were also blocked by reduced interaction of sema6D with plexin-A1. These findings suggest that interaction of plexin-A1 and sema6D mediates activation signals for both DCs and T cells.
(This work is supported by National Institutes of Health Grant AI29564).
