-
Views
-
Cite
Cite
Giorgio Raimondi, Ivan Zanoni, Stefania Citterio, Paola Ricciardi-Castagnoli, Francesca Granucci, Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. II. Chronic Antigen Presentation Overrules Antigen-Presenting B Cell Activation, The Journal of Immunology, Volume 176, Issue 7, April 2006, Pages 4021–4028, https://doi.org/10.4049/jimmunol.176.7.4021
Close - Share Icon Share
Abstract
Ag presentation in the absence of danger signals and Ag persistence are the inductive processes of peripheral T cell tolerization proposed so far. Nevertheless, it has never been definitively shown that chronic Ag presentation per se can induce T cell tolerance independent of the state of activation of APCs. In the present work, we investigated whether chronic Ag presentation by either resting or activated B cells can induce tolerance of peripheral Ag-specific T cells. We show that CD4+ T cells that re-encounter the Ag for a prolonged period, presented either by resting or activated Ag-presenting B cells, become nonfunctional and lose any autoimmune reactivity. Thus, when the main APCs are B cells, the major mechanism responsible for peripheral T cell tolerization is persistent Ag exposure, independent of the B cell activation state.
