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Susumu Nakae, Masahide Asano, Reiko Horai, Nobuo Sakaguchi, Yoichiro Iwakura, IL-1 Enhances T Cell-Dependent Antibody Production Through Induction of CD40 Ligand and OX40 on T Cells, The Journal of Immunology, Volume 167, Issue 1, July 2001, Pages 90–97, https://doi.org/10.4049/jimmunol.167.1.90
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Abstract
IL-1 is a proinflammatory cytokine that plays pleiotropic roles in host defense mechanisms. We investigated the role of IL-1 in the humoral immune response using gene-targeted mice. Ab production against SRBC was significantly reduced in IL-1α/β-deficient (IL-1−/−) mice and enhanced in IL-1R antagonist−/− mice. The intrinsic functions of T, B, and APCs were normal in IL-1−/− mice. However, we showed that IL-1−/− APCs did not fully activate DO11.10 T cells, while IL-1R antagonist −/− APCs enhanced the reaction, indicating that IL-1 promotes T cell priming through T-APC interaction. The function of IL-1 was CD28-CD80/CD86 independent. We found that CD40 ligand and OX40 expression on T cells was affected by the mutation, and the reduced Ag-specific B cell response in IL-1−/− mice was recovered by the treatment with agonistic anti-CD40 mAb both in vitro and in vivo. These observations indicate that IL-1 enhances T cell-dependent Ab production by augmenting CD40 ligand and OX40 expression on T cells.
