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Hung-Rong Yen, Timothy J Harris, Satoshi Wada, Joseph F Grosso, Derese Getnet, Monica V Goldberg, Kai-Li Liang, Tullia C Bruno, Kristin J Pyle, Siaw-Li Chan, Robert A Anders, Cornelia L Trimble, Adam J Adler, Tzou-Yien Lin, Drew M Pardoll, Ching-Tai Huang, Charles G Drake, Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity, The Journal of Immunology, Volume 183, Issue 11, December 2009, Pages 7161–7168, https://doi.org/10.4049/jimmunol.0900368
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Abstract
IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little is known regarding their functional characteristics. While Tc1 cells produced IFN-γ and efficiently killed targets, Tc17 cells lacked lytic function in vitro. Interestingly, the small numbers of IFN-γ-positive or IL-17/IFN-γ-double-positive cells generated under Tc17 conditions also lacked lytic activity and expressed a similar pattern of cell surface proteins to IL-17-producing cells. As is the case for Th17 (CD4) cells, STAT3 is important for Tc17 polarization, both in vitro and in vivo. Adoptive transfer of highly purified, Ag-specific IL-17-secreting Tc17 cells into Ag-bearing hosts resulted in near complete conversion to an IFN-γ-secreting phenotype and substantial pulmonary pathology, demonstrating functional plasticity. Tc17 also accumulated to a greater extent than did Tc1 cells, suggesting that adoptive transfer of CD8 T cells cultured in Tc17 conditions may have therapeutic potential for diseases in which IFN-γ-producing cells are desired.