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Kexin Jiang, Yanjiani Xu, Yan Wang, Nanhao Yin, Fangyang Huang, Mao Chen, Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease, The Journal of Immunology, 2025;, vkaf061, https://doi.org/10.1093/jimmun/vkaf061
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Abstract
This review explores interleukin (IL)-17D and its receptor CD93, highlighting their structural, functional, and clinical aspects. Identifying CD93 as the receptor for IL-17D has advanced understanding of the IL-17 family and its signaling pathways. IL-17D, with its unique glycoprotein structure, plays diverse roles in oxidative stress response and potential antitumor therapies. It is involved in autoimmune diseases, infections, and cancers, making it a promising therapeutic target. CD93 is crucial in various biological processes, from angiogenesis to inflammatory diseases. CD93's implications in cancers, neuroinflammation, and metabolism highlight its significance as a potential prognostic marker and therapeutic target. The review emphasizes IL-17D and CD93 as promising areas for future research, offering insights into their signaling pathways and potential applications in personalized medicine. Deciphering the relationship between IL-17D and CD93 is in its infancy and invites exploration for transformative advancements in immunology and beyond.