Correction to: “Presentation and Management of Highly Differentiated Follicular Carcinoma of Ovarian Origin With DICER1 Gene Variants” Open Access

In the above-named article by Seav S, Atiq M, Lo YC, Shah J, Dorigo O, and Dosiou C (JCEM Case Reports. 2024; 2(12); doi: 10.1210/jcemcr/luae223), there were errors in the abstract and the Diagnostic Assessment section.

In the originally published article, the sixth sentence in the abstract read “A second variant (c.319delins13, exon 4) was of uncertain significance.” For clarification and consistency, “c.319delins13” has been expanded as “c.319delinsTGCTGGTTTGACA.” In the corrected article, the sentence now reads “A second variant (c.319delinsTGCTGGTTTGACA, exon 4) was of uncertain significance.”

In the originally published article, in the second paragraph of the Diagnostic Assessment section, the second sentence read “Molecular testing of omental biopsies (estimated tumor purity of 40%) revealed 2 DICER1 gene alterations: 1) a pathogenic variant (c.5428G>T, p.D1810, exon 25) with a variant allele frequency of 28.6% and 2) a variant of undetermined significance (VUS) (c.319delins13, p.Ala107delinsCysTrpAspThr, exon 4) with a variant allele frequency of 40.5%.” For clarification and consistency, “c.319delins13” has been expanded as “c.319delinsTGCTGGTTTGACA.” Also, the corresponding protein nomenclature “p.Ala107delinsCysTrpAspThr” is incorrect, so “Phe” has been added to form “p.Ala107delinsCysTrpPheAspThr.” In the corrected article, the sentence now reads “Molecular testing of omental biopsies (estimated tumor purity of 40%) revealed 2 DICER1 gene alterations: 1) a pathogenic variant (c.5428G>T, p.D1810, exon 25) with a variant allele frequency of 28.6% and 2) a variant of undetermined significance (VUS) (c.319delinsTGCTGGTTTGACA, p.Ala107delinsCysTrpPheAspThr, exon 4) with a variant allele frequency of 40.5%.”

In the originally published article, in the third paragraph of the Diagnostic Assessment section, the second sentence read “The detected DICER1 variant was c.319delinsTCTGGTTTGACA (p.Ala107delinsCysTrpAspThr, exon 4)—the same VUS identified in the omental biopsy as described earlier.” The phrase “c.319delinsTCTGGTTTGACA” excluded a guanine nucleotide, so “G” has been added to correct it to “c.319delinsTGCTGGTTTGACA.” Also, “p.Ala107delinsCysTrpAspThr” is incorrect and has been replaced with “p.Ala107delinsCysTrpPheAspThr.” In the corrected article, the sentence now reads “The detected DICER1 variant was c.319delinsTGCTGGTTTGACA (p.Ala107delinsCysTrpPheAspThr, exon 4)—the same VUS identified in the omental biopsy as described earlier.”

The authors report that these errors in the coding and protein nomenclature of one of the DICER1 gene variants do not change their originally published interpretation of this genetic variation and its implication in their patient's clinical presentation.

The article has been corrected online.

doi: 10.1210/jcemcr/luae223