-
Views
-
Cite
Cite
Sang Yhun Ju, Hyun Suk Jeong, Do Hoon Kim, Blood Vitamin D Status and Metabolic Syndrome in the General Adult Population: A Dose-Response Meta-Analysis, The Journal of Clinical Endocrinology & Metabolism, Volume 99, Issue 3, 1 March 2014, Pages 1053–1063, https://doi.org/10.1210/jc.2013-3577
Close - Share Icon Share
Increasing evidence has suggested an association between blood vitamin D levels and metabolic syndrome.
Our objective was to determine the relationship between blood vitamin D status and metabolic syndrome in the general adult population, using a dose-response meta-analysis.
We searched the PubMed, EMBASE, Web of Science, and Cochrane Library databases through July 2013 to identify relevant studies.
Observational studies, reporting risk ratios with a 95% confidence interval (CI) for metabolic syndrome in ≥3 categories of blood 25-hydroxyvitamin D [25(OH)D] levels, were selected.
Data extraction was performed independently by 2 authors, and the quality of the studies was evaluated using the risk of bias assessment tool for nonrandomized studies.
The pooled odds ratio of metabolic syndrome per 25 nmol/L increment in the serum/plasma 25(OH)D concentration was 0.87 (95% CI = 0.83–0.92, I2 = 85%), based on 16 “cross-sectional studies” and 1.00 (95% CI = 0.98–1.02, I2 = 0%) for 2 “cohort and nested case-control studies.” The dose-response meta-analysis showed a generally linear, inverse relationship between 25(OH)D levels and metabolic syndrome in the cross-sectional studies (P for linear trend < .001).
Blood vitamin D levels were associated with a risk of metabolic syndrome in cross-sectional studies but not in longitudinal studies. Randomized, clinical trials will be necessary to address the issue of causality and to determine whether vitamin D supplementation is effective for the prevention of metabolic syndrome.
