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C. Bellevicine, S. Ippolito, D. Arpaia, G. Ciancia, G. Pettinato, G. Troncone, B. Biondi, Ultimobranchial Body Remnants (Solid Cell Nests) as a Pitfall in Thyroid Pathology, The Journal of Clinical Endocrinology & Metabolism, Volume 97, Issue 7, 1 July 2012, Pages 2209–2210, https://doi.org/10.1210/jc.2012-1034
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Case History
We report the history of a pitfall in thyroid histopathology of a 47-yr-old man with a euthyroid nodular goiter involving the right lobe. The ultrasound-guided fine-needle aspiration of the dominant (3 cm) nodule, showing benign-appearing follicular cells, colloid, and scattered Hürthle cells, was consistent with a benign hyperplastic nodule (1). Because the left lobe had not shown evidence of nodular disease, the patient was submitted to a right lobectomy. The pathologist described a heavy lymphoplasmacytic background with occasional germinal center formation, as observed in Hashimoto thyroiditis, and a microscopic (<1 cm) follicular proliferation of epithelial thyroid cells whose nuclei displayed membrane irregularity and chromatin clearing with occasional grooves. Thus, a histological report of a follicular variant of papillary microcarcinoma was issued. The patient underwent a completion thyroidectomy at the Federico II University of Naples. At that occasion, the complete set of slides from both surgeries was reviewed by expert pathologists in the field of thyroid disease.