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Rasmus Sode-Carlsen, Stense Farholt, Kai Fr. Rabben, Jens Bollerslev, Thomas Schreiner, Anne Grethe Jurik, Jens Sandahl Christiansen, Charlotte Höybye, One Year of Growth Hormone Treatment in Adults with Prader-Willi Syndrome Improves Body Composition: Results from a Randomized, Placebo-Controlled Study, The Journal of Clinical Endocrinology & Metabolism, Volume 95, Issue 11, 1 November 2010, Pages 4943–4950, https://doi.org/10.1210/jc.2010-0907
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Context: Prader-Willi syndrome (PWS) is a multisymptomatic disease that shares many similarities with the GH deficiency syndrome, including altered body composition with more body fat than lean body mass.
Objective: Our objective was to investigate the effect of GH on body composition in adults with PWS.
Design and patients: Forty-six adults with PWS were randomized to GH or placebo treatment for 12 months in a double-blind trial.
Main Outcome Measures: We evaluated change in regional body composition of the abdomen and thigh as measured by computed tomography and change in total body composition as measured by dual-energy x-ray absorptiometry.
Results: Forty patients completed the study. Baseline median IGF-I sd score was −0.4. GH treatment increased IGF-I by 125 μg/liter (1.51 sd score), and based upon computed tomography, body composition improved with a decrease in visceral fat mass of 22.9 ml (P = 0.004), abdominal sc fat mass 70.9 ml (P = 0.003), and thigh fat mass 21.3 ml (P = 0.013), whereas thigh muscle mass increased 6.0 ml (P = 0.005). By dual-energy x-ray absorptiometry, lean body mass improved 2.25 kg (P = 0.005), and total fat mass decreased 4.20 kg (P < 0.001). No major side effects were seen.
Conclusion: Unrelated to the GH-IGF-I levels at baseline, our results showed that long-term treatment with GH effectively improved body composition and represents a safe, potential treatment option, relieving some of the negative consequences of PWS.