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Eiji Kawasaki, Takuya Awata, Hiroshi Ikegami, Tetsuro Kobayashi, Taro Maruyama, Koji Nakanishi, Akira Shimada, Miho Uga, Susumu Kurihara, Yumiko Kawabata, Shoichiro Tanaka, Yasuhiko Kanazawa, Katsumi Eguchi, Genetic Association between the Interleukin-2 Receptor-α Gene and Mode of Onset of Type 1 Diabetes in the Japanese Population, The Journal of Clinical Endocrinology & Metabolism, Volume 94, Issue 3, 1 March 2009, Pages 947–952, https://doi.org/10.1210/jc.2008-1596
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Abstract
Context/Objective: The IL-2 receptor-α (IL2RA), also known as CD25, is expressed on the regulatory T cells, which play an important role in the control of immune responses and the maintenance of immune homeostasis. Our objective was to determine whether variants in the IL2RA gene are associated with type 1 diabetes in the Japanese population.
Design/Patients: We genotyped the four single-nucleotide polymorphisms (rs706778, rs3118470, ss52580101, and rs11594656) of the IL2RA in 885 patients with type 1 diabetes and 606 control subjects of Japanese origin. The allele and genotype frequencies were examined in the patient groups stratified by their mode of onset in a case-control study.
Results: We found evidence of association with acute-onset, but not slow-onset and fulminant, type 1 diabetes for two of the four single-nucleotide polymorphisms genotyped (rs706778 and rs3118470). The rs706778 A allele and the rs3118470 G allele were associated with an increased disease risk [odds ratio (OR) for rs706778 AA genotype 1.54, P = 4.2 × 10−4 and OR for rs3118470 GG genotype 1.50, P = 0.0019, respectively]. Furthermore, the A-G haplotype was associated with increased type 1 diabetes risk in the acute-onset form (OR 1.30, P = 0.002).
Conclusions: The present data confirm the type 1 diabetes association with IL2RA and provide evidence that the different contributions of the IL2RA in the susceptibility to acute-onset and other forms of type 1 diabetes in the Japanese population.
