-
Views
-
Cite
Cite
Lijun Ma, Robert L. Hanson, Lorem N. Que, Janel L. Mack, Paul W. Franks, Aniello M. Infante, Sayuko Kobes, Clifton Bogardus, Leslie J. Baier, Association Analysis of Krüppel-Like Factor 11 Variants with Type 2 Diabetes in Pima Indians, The Journal of Clinical Endocrinology & Metabolism, Volume 93, Issue 9, 1 September 2008, Pages 3644–3649, https://doi.org/10.1210/jc.2008-0546
Close - Share Icon Share
Context: Krüppel-like factor 11 (KLF11) is a transcription factor of the zinc finger domain family that has been shown to regulate expression of the insulin gene. An initial study reported that a KLF11 variant predicting a Q62R was associated with type 2 diabetes (T2D) in French Caucasians; however, subsequent studies have failed to identify an association between this variant and T2D in subjects from a similar Northern-European ancestry.
Objective: We sought to determine whether the Q62R or other variants within KLF11 were associated with T2D in Pima Indians, a population with an extremely high prevalence of this disease.
Design, Setting, and Subjects:KLF11 was sequenced in 24 Pima Indians to identify potentially novel variants. There were 18 variants genotyped in a family-based sample of 1337 Pima Indians to analyze the linkage disequilibrium pattern of this gene and identify representative variants. Four representative variants were further genotyped in a population-based sample of 3501 full-heritage Pima Indians for association analyses. Among these subjects, 413 had undergone metabolic studies when they were nondiabetic to measure traits that predict T2D.
Results: Neither the Q62R nor any other common variant in KLF11 was associated with T2D in the Pima population. In addition, no variant was associated with insulin secretion or insulin-stimulated glucose disposal rate.
Conclusions: Common variation in KLF11 variation does not appear to influence the population-based risk for developing T2D among full-heritage Pima Indians. Thus, KLF11 is unlikely to play a major role in the etiology of T2D among this Native American population.
