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Kurt A. Mossberg, Brent E. Masel, Charles R. Gilkison, Randall J. Urban, Aerobic Capacity and Growth Hormone Deficiency after Traumatic Brain Injury, The Journal of Clinical Endocrinology & Metabolism, Volume 93, Issue 7, 1 July 2008, Pages 2581–2587, https://doi.org/10.1210/jc.2008-0368
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Abstract
Context: GH deficiency occurs in approximately 20% of all individuals who suffer from a moderate to severe traumatic brain injury.
Objective: This study determined whether GH deficiency secondary to traumatic brain injury had an effect on aerobic capacity.
Design: Subjects were screened for GH deficiency by the glucagon stimulation test and performed a maximal treadmill exercise test.
Setting: Patients were studied in the postacute recovery phase after traumatic brain injury.
Participants: Thirty-five individuals were studied. Groups were formed as follows: normal GH axis, greater than 8 ng/ml response (n = 12); insufficient, GH 3–8 ng/ml response (n = 11); and deficient, less than 3 ng/ml response (n = 12).
Intervention: There was no intervention.
Main Outcome Measure: Aerobic capacity was assessed by measuring expired gases during a graded treadmill exercise test. One-way and two-way ANOVAs were carried out on all peak and submaximal cardiorespiratory variables, respectively. Appropriate post hoc comparisons followed as necessary.
Results: Significantly higher peak oxygen consumption was found in traumatic brain injury subjects with GH normal vs. GH insufficient and deficient [26.4 ± 6.9, 20.8 ± 4.6, and 19.7 ± 5.0, respectively (P < 0.05)]. Submaximal oxygen consumption was significantly higher in the GH normal group. All other variables were statistically similar.
Conclusions: This study shows that individuals with traumatic brain injury with normal GH secretion have below normal aerobic capacity and those patients who have GH insufficiency/deficiency are further deconditioned. Studies of GH replacement in these subjects should be conducted to assess whether GH therapy can improve cardiorespiratory fitness and prevent secondary disability.
