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Maya B. Lodish, Anathea C. Powell, Mones Abu-Asab, Craig Cochran, Petra Lenz, Steven K. Libutti, James F. Pingpank, Maria Tsokos, Phillip Gorden, Insulinoma and Gastrinoma Syndromes from a Single Intrapancreatic Neuroendocrine Tumor, The Journal of Clinical Endocrinology & Metabolism, Volume 93, Issue 4, 1 April 2008, Pages 1123–1128, https://doi.org/10.1210/jc.2007-2449
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Abstract
Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously.
Objective: Our objective was to determine the cause of a patient’s hypoglycemic episodes and peptic ulcer disease.
Design and Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health.
Patient and Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor.
Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative.
Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.