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Endocrine Discovery

Type 2 diabetes was strongly associated with a variant transcription factor 7-like 2 gene (TCF7L2) in an Icelandic population, a finding replicated in Danish and U.S. cohorts. Heterozygous and homozygous carriers of the variant allele(s) had relative risks of 1.45 and 2.41, respectively. TCF7L2 is a transcription factor believed to regulate expression of the proglucagon gene in enteroendocrine cells.
(
Nat Genet
(January 15, 2006))
In a randomized controlled trial, intensive insulin therapy in 1200 patients did not significantly lessen the overall group’s in-hospital mortality, although lower incidences of new renal injury, faster weaning from mechanical ventilation, and earlier ICU discharge were seen. Among patients who ultimately stayed in the ICU for more than three days, mortality was lower (43% vs. 53%, P = 0.009), but they could not be distinguished in advance from those with shorter stays, in whom mortality was actually increased.
(
N Engl J Med
(Feb. 2, 2006) 354:449)
Issue Section:
The Endocrine Society
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