-
Views
-
Cite
Cite
C. L. ROBBINS, E. B. MAN, ABSORPTION AND CLINICAL EFFECT OF A LARGE SINGLE DOSE OF THYROID GLOBULIN, The Journal of Clinical Endocrinology & Metabolism, Volume 9, Issue 4, 1 April 1949, Pages 377–381, https://doi.org/10.1210/jcem-9-4-377
Close - Share Icon Share
Abstract
PREVIOUS papers have described a clinical condition similar to hyperthyroidism resulting from continuous ingestion of excessive amounts of desiccated thyroid (1, 2, 3, 4, 5, 6).
In the case to be reported there were no toxic effects, although a serum precipitable iodine of 40.9 gamma per cent established the fact that a great part of a single huge dose of thyroid globulin had been absorbed.
The patient, M. W., a 31-year-old married white woman, consulted her physician in the latter part of June 1947 regarding her obesity. For two years following her first parturition in 1934, when she was 18 years old, she had weighed 117 pounds. After a right salpingo-oophorectomy and appendectomy at the age of 20, and following a second pregnancy in 1938, her weight was 160 pounds. This increased after her third pregnancy in 1945 to 248 pounds.
The patient's physician prescribed a low calorie diet and 3 grains of thyroid daily. During the first nine days of July 1947 the patient took a total of 27, one-grain, “Proloid” (Maltine) tablets. On the morning of July 10, 1947 the patient took all the tablets remaining in the box, presumably 63 tablets, in a single dose.
