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Michael R. Rickels, Jill E. Langer, Susan J. Mandel, Hyperfunctioning Intrathyroidal Parathyroid Cyst, The Journal of Clinical Endocrinology & Metabolism, Volume 89, Issue 3, 1 March 2004, Pages 1051–1052, https://doi.org/10.1210/jc.2003-031844
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A 54-yr-old man had nephrolithiasis attributed to primary hyperparathyroidism based on elevated concentrations of serum calcium [11.4 mg/dl (2.8 mmol/liter); normal, 8.5–10.6 mg/dl (2.1–2.6 mmol/liter)], serum intact PTH [151 pg/ml (16 pmol/liter); normal, 12–72 pg/ml (1.3–7.6 pmol/liter)], and 24-h urine calcium [271 mg (6.8 mmol); normal, <200 mg (5.0 mmol)]. Figure 1 depicts the preoperative imaging. A planar parathyroid scan performed 2 h after the administration of technetium sestamibi demonstrated persistent uptake at the right lower pole of the thyroid (Fig. 1A, arrow), a result consistent with the presence of a parathyroid adenoma. An ultrasound evaluation demonstrated a 1.7-cm predominantly cystic nodule in the right lower pole of the thyroid (Fig. 1B, circle), and ultrasound-guided fine-needle aspiration yielded epithelial cells possibly representing parathyroid tissue. A subsequent needle pass attempting to sample the cyst fluid yielded bloody material of insufficient quantity to analyze for intact PTH.
A right hemithyroidectomy revealed a 1.8-cm parathyroid cyst in the lower lobe. Two months postoperatively, the concentrations of serum calcium [9.0 mg/dl (2.2 mmol/liter)], serum intact PTH [34 pg/ml (3.6 pmol/liter)], and 24-h urine calcium [165 mg (4.1 mmol)] were normal.