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Michael B. Ranke, Anders Lindberg, David D. Martin, Bert Bakker, Patrick Wilton, Kerstin Albertsson-Wikland, Chris T. Cowell, David A. Price, Edward O. Reiter, The Mathematical Model for Total Pubertal Growth in Idiopathic Growth Hormone (GH) Deficiency Suggests a Moderate Role of GH Dose, The Journal of Clinical Endocrinology & Metabolism, Volume 88, Issue 10, 1 October 2003, Pages 4748–4753, https://doi.org/10.1210/jc.2003-030600
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Abstract
The role of GH treatment during total pubertal growth (TPG) is still unclear. We developed a prediction model for TPG (centimeters) through a multiple regression analysis of various prepubertal parameters in 303 adolescents with idiopathic GH deficiency from the KIGS database. Prepubertal catch-up growth and near-adult height were achieved, and GH dose was kept constant at approximately 30 μg/kg·d. The model was validated on a cohort of 36 patients from one center. Four TPG predictors explained 70% of the variability with an error sd of 4.2 cm: gender (TPG in males was >11.3 cm vs. that in females), age at onset of puberty (negative), height sd score minus midparental height sd score at puberty onset (negative), and mean GH dose during puberty (positive). Our analysis suggests that TPG in idiopathic GH deficiency is only moderately dependent on GH dose. The use of a higher GH dosage at the onset of puberty should thus depend on the individual’s height development. The TPG model aids in the planning of individually optimized and cost-effective GH treatment.
