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Barbara B. Sherwin, “Add-Back” Estrogen Reverses Cognitive Deficits Induced by a Gonadotropin-Releasing Hormone Agonist in Women with Leiomyomata Uteri—Author’s Response, The Journal of Clinical Endocrinology & Metabolism, Volume 82, Issue 2, 1 February 1997, Pages 702–703, https://doi.org/10.1210/jcem.82.2.3771-3
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I would like to address some of the concerns expressed by Dr. Davis regarding the conclusions of our recent publication in The Journal of Clinical Endocrinology and Metabolism (1).
There were several indices of hypoestrogenism in these women, treated for 3 months with leuprolide acetate depot (LAD), that led us to conclude that they were relatively estrogen deficient. As Table 3 in that article shows, FSH levels increased in all women by 3 months post-treatment compared with pretreatment values, although the increase failed to attain conventional levels of statistical significance. Plasma estradiol levels decreased significantly during the same 2 points in time. Finally, the volume of the uterine myomas, as measured by repeated ultrasonography, also decreased significantly after 12 weeks of LAD treatment as we reported. Indeed, the fact that these estrogen-dependent myomas shrink in size when deprived of estrogen provides the rationale for treatment with LAD before their surgical removal. Taken together, the consistency in these different lines of evidence permits the conclusion that the patients in this study had indeed been rendered estrogen deficient.
