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T. H. JONES, S. JUSTICE, A. PRICE, K. CHAPMAN, INTERLEUKIN-6 SECRETING HUMAN PITUITARY ADENOMAS IN VITRO, The Journal of Clinical Endocrinology & Metabolism, Volume 73, Issue 1, 1 July 1991, Pages 207–209, https://doi.org/10.1210/jcem-73-1-207
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Abstract
Interleukin-6 was found to be secreted from seven out of ten human pituitary tumours cultured in vitro. These tumours included prolactin-secreting, growth hormone-secreting and clinically non-functioning adenomas. The amount of Interleukin-6 secreted was variable from 58 to 10,000 units per ml. in medium removed after a four-day incubation under basal conditions. Four tumours secreted IL-6 in excess of 500U/ml, three of which were clinically non-functioning, but each secreted follicle stimulating hormone in vitro. This is the first report of a cytokine growth factor being released basally by human pituitary tumours.