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ROBERT C. MOEHLIG, ADDISON'S DISEASE FOLLOWED FOR NINE YEARS: CASE REPORT WITH AUTOPSY, The Journal of Clinical Endocrinology & Metabolism, Volume 7, Issue 2, 1 February 1947, Pages 134–151, https://doi.org/10.1210/jcem-7-2-134
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Abstract
BECAUSE of the newer methods of treatment, the life of patients with Addison's disease has been extended for several years. The influence this new form of therapy has on longevity, and its effects on body tissues, warrants reporting a case followed for nine years. Furthermore, the fact that this patient's pigmentation underwent marked changes, either spontaneously or because of the therapy, is an additional reason for this report.
This case was previously reported in the October 1940 issue of Endocrinology (2), at which time it was summarized as follows:
“A case is reported in a 31 year old male patient who presented all the clinical criteria for the diagnosis of Addison's disease. The patient had been on adrenal cortex extract and sodium chloride, discontinuance of which resulted in an Addisonian crisis. Desoxycorticosterone acetate was given six times a week in 5 mg. doses for two months. Subsequent to this, 600 mg. of desoxycorticosterone acetate, in the form of four pellets of 150 mg. each, were implanted in the abdominal muscles. Marked general improvement, gain in weight, and a substantial increase in blood pressure resulted from this form of therapy. The improvement has been maintained over a period of five months. There has been no noticeable change in the pigmentation of the skin.”
