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JOHN R. BRUMSTED, JANE CHAPITIS, DANIEL RIDDICK, MARK GIBSON, Norethindrone Inhibition of Testosterone Secretion by an Ovarian Sertoli-Leydig Cell Tumor, The Journal of Clinical Endocrinology & Metabolism, Volume 65, Issue 1, 1 July 1987, Pages 194–197, https://doi.org/10.1210/jcem-65-1-194
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A woman with severe hyperandrogenemia and virilization was found to have a fall in serum testosterone (T) concentration while taking an oral contraceptive containing norethindrone (500 vs. 164 ng/dL). Subsequent surgical exploration revealed an ovarian Sertoli-Leydig cell tumor. In vitro, the tumor secreted T (mean, 1.88 ng/mg·4 h). hCG did not stimulate T secretion. In addition, norethindrone inhibited T secretion (0.33 ng/mg·4 h). We conclude that norethindrone directly suppressed T production by the Sertoli-Leydig cell tumor.