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T. KRARUP, S. MADSBAD, A. J. MOODY, Immunoreactive Gastric Inhibitory Polypeptide Response to a Meal during the First Eighteen Months after Diagnosis of Type 1 (Insulin Dependent) Diabetes Mellitus, The Journal of Clinical Endocrinology & Metabolism, Volume 60, Issue 1, 1 January 1985, Pages 120–125, https://doi.org/10.1210/jcem-60-1-120
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Abstract
The changes in plasma concentrations of immunoreactive gastric inhibitory polypeptide (IR-GIP) in response to a standard meal were examined in 21 normal subjects and 15 Type 1 (insulin dependent) diabetic patients 7 days, 14 days, and 3, 6, 9, 12, and 18 months after time of diagnosis. During the first 4 tests significantly lower plasma IR-GIP concentrations were found in the diabetic patients after the standard meal. At 9 months and during the remaining tests there was no difference in IR-GIP concentrations between the diabetic and the normal subjects. The IR-GIP response was normalized faster if the diabetic patients were treated with initial short term intensive insulin therapy than if they were treated conventionally with 1 or 2 daily injections of insulin.
β-Cell function, evaluated by the C-peptide response to the meal, increased significantly during the first 3 months. After 3 months maximal β-cell function was found while the corresponding IR-GIP responses were significantly lower than those of the normal subjects. Thereafter β-cell function declined gradually and significantly, coinciding with the normalization of the IRGIP response. No individual covariation between IR-GIP and β-cell function during the 18 months was found in any patient.
The IR-GIP response to a meal was diminished at the onset of Type 1 (insulin dependent) diabetes mellitus. After the start of insulin therapy the response improved, perhaps as a function of the quality of metabolic control, and within a year it was comparable to that of normal subjects. Lack of endogenous GIP therefore does not explain the diminished β-cell function in Type 1 diabetes a few months after onset of the disease. No causal relationship between the changes in β-cell function and IR-GIP during the first 18 months after the onset of the disease seems to exist.
