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J.H. Liu, K. Muse, P. Contreras, D. Gibbs, W. Vale, J. Rivier, S. S. C. Yen, AUGMENTATION OF ACTH-RELEASING ACTIVITY OP SYNTHETIC CORTICOTROPIN RELEASING FACTOR (CRF) BY VASOPRESSIN IN WOMEN, The Journal of Clinical Endocrinology & Metabolism, Volume 57, Issue 5, 1 November 1983, Pages 1087–1089, https://doi.org/10.1210/jcem-57-5-1087
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In order to study the interaction between vasopressin (VP) and hypothalamic corticotropin releasing factor (CRF) on the release of ACTH, VP and CRF were administered separately and in combination to normal cycling women. The combined hormones raised plasma ACTH levels higher than the sum of the separate responses and 5 times more than CRF alone. This study reveals for the first time synergism between VP and CRF in their ACTH releasing effects in humans.