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MIKIRO ISEKI, MAKOTO SHIMIZU, TADAO OIKAWA, HIDETO HOJO, KAZUMI ARIKAWA, YOICHI ICHIKAWA, NAOKO MOMOTANI, KUNIHIKO ITO, Sequential Serum Measurements of Thyrotropin Binding Inhibitor Immunoglobulin G in Transient Familial Neonatal Hypothyroidism, The Journal of Clinical Endocrinology & Metabolism, Volume 57, Issue 2, 1 August 1983, Pages 384–387, https://doi.org/10.1210/jcem-57-2-384
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Abstract
Infants with transient neonatal hypothyroidism, in whom TSH binding inhibitor immunoglobulin G (IgG) (TBII) were sequentially measured, are described. Their mother had been taking thyroid replacement for hypothyroidism due to nongoitrous autoimmune thyroiditis. IgGs inhibiting TSH binding were detected in maternal sera by radioreceptor assay. These IgGs also inhibited the adenylate cyclase response to TSH in human thyroid membranes. Three infants had frank hypothyroidismhypothyroidism immediately after birth, and TBII were detected in two of them. In the two surviving infants, hypothyroidism was transient and improved when TBII disappeared from their sera. The profile of TBII in one patient corresponded to the IgG disappearance curve. These findings suggest that the transient neonatal hypothyroidism reported was caused by transplacental transfer of TBII. J Clin Endocrinol Metab57: 384, 1983)