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Fred P. Mandel, R. Jeffrey Chang, B. Dupont, Marilyn S. Pollack, Lenore S. Levine, Maria I. New, John K. H. Lu, Howard L. Judd, HLA Genotyping in Family Members and Patients with Familial Polycystic Ovarian Disease, The Journal of Clinical Endocrinology & Metabolism, Volume 56, Issue 4, 1 April 1983, Pages 862–864, https://doi.org/10.1210/jcem-56-4-862
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To determine whether the familial occurrence of polycystic ovarian disease (PCO) is related to the major histocompatibility complex (HLA), four families in whom at least two siblings had clinical evidence of disease were examined. The diagnosis of PCO was confirmed by increased serum testosterone, androstenedione, and LH levels compared to those in normal women. Elevated concentrations of dehydroepiandrosterone sulfate indicated excess adrenal androgen secretion. The result of HLA genotyping in the families studied demonstrate that PCO does not exhibit linkage to the HLA system. (J Clin Endocrinol Metab56: 862, 1983)