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DECIO ARMANINI, GARY J. GOLAND, WILLIAM R. ADAM, JOHN W. FUNDER, Cyproheptadine and Mineralocorticoid Effector Mechanisms, The Journal of Clinical Endocrinology & Metabolism, Volume 56, Issue 2, 1 February 1983, Pages 397–400, https://doi.org/10.1210/jcem-56-2-397
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Abstract
Cyproheptadine has recently been reported to blunt the furosemide-induced rise in PRA in normal subjects and to acutely lower plasma aldosterone levels in patients with hyperaldosteronism due to bilateral adrenal hyperplasia; both actions have tentatively been ascribed to the antiserotoninergic action of the drug. We here describe receptor studies showing cyproheptadine to occupy mineralocorticoid, but not glucocorticoid, receptors in rat and mouse kidney. On bioassay, cyproheptadine is a partial mineralocorticoid agonist/predominant antagonist.